» Articles » PMID: 17008790

Efficacy of S-1 for Patients with Peritoneal Metastasis of Gastric Cancer

Overview
Journal Chemotherapy
Specialty Pharmacology
Date 2006 Sep 30
PMID 17008790
Citations 16
Authors
Affiliations
Soon will be listed here.
Abstract

Background: This study was designed to examine the efficacy and compliance of S-1 for the patients with peritoneal metastasis of gastric cancer.

Methods: Sixteen consecutive patients with peritoneal metastasis of gastric cancer were treated with S-1. Their survival was compared with that of the historical control group (25 patients). Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase and orotate phosphoribosyl transferase mRNA expression in the tumor were evaluated.

Results: The median survival time of S-1-treated patients was 550 days, which was significantly longer than that of the historical control group (215 days). We elucidated some factors to prolong the survival of the patients treated with S-1 for peritoneal metastasis: peritoneal metastasis without other distant metastases, the combination of S-1 treatment and gastrectomy, and low expression of thymidine phosphorylase mRNA in primary tumors.

Conclusions: S-1 showed a surprisingly long-term survival with minimum toxicity in patients with peritoneal metastasis of gastric cancer.

Citing Articles

N-methyladenosine-modified MIB1 promotes stemness properties and peritoneal metastasis of gastric cancer cells by ubiquitinating DDX3X.

Xu P, Liu K, Huang S, Lv J, Yan Z, Ge H Gastric Cancer. 2024; 27(2):275-291.

PMID: 38252226 DOI: 10.1007/s10120-023-01463-5.


Oncolytic Virotherapy in Peritoneal Metastasis Gastric Cancer: The Challenges and Achievements.

Shao S, Yang X, Zhang Y, Wang X, Li K, Zhao Y Front Mol Biosci. 2022; 9:835300.

PMID: 35295845 PMC: 8918680. DOI: 10.3389/fmolb.2022.835300.


Noncoding RNAs and hyperthermic intraperitoneal chemotherapy in advanced gastric cancer.

Zeng L, Liao Q, Zeng X, Ye J, Yang X, Zhu S Bioengineered. 2022; 13(2):2623-2638.

PMID: 35089117 PMC: 8973587. DOI: 10.1080/21655979.2021.2021348.


The benefits of surgery plus extensive intraoperative peritoneal lavage (EIPL) for patients with gastric cancer compared with surgery alone: a systematic review and meta-analysis.

Li S, Li L, Tan B, Wang J, Xue S Updates Surg. 2021; 74(1):65-72.

PMID: 34170498 DOI: 10.1007/s13304-021-01120-5.


LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target.

Kang X, Li W, Liu W, Liang H, Deng J, Wong C Oncogene. 2021; 40(19):3422-3433.

PMID: 33883692 PMC: 8116207. DOI: 10.1038/s41388-021-01656-1.