Nonketotic Hyperglycemic Coma in Toddlers After Unintentional Methadone Ingestion
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Methadone overdoses are increasing in parallel with the increased frequency of opiate substitution therapy in adults. Although unintentional methadone intoxication in children is rare, it is becoming more frequently recognized. We report 3 cases of unintentional methadone overdose in toddlers who initially displayed central nervous system depression associated with severe nonketotic hyperglycemia and discuss the possible pathophysiologic mechanisms of an underrecognized symptom of opiate intoxication in young children.
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Dupuy G, Cavalcanti L, Bourgogne E, Brichant-Petitjean C, Gomberoff L, Bloch V Harm Reduct J. 2014; 11:20.
PMID: 24990630 PMC: 4094677. DOI: 10.1186/1477-7517-11-20.
Aghabiklooei A, Hassanian-Moghaddam H, Zamani N, Shadnia S, Mashayekhian M, Rahimi M Biomed Res Int. 2013; 2013:903172.
PMID: 24089691 PMC: 3781921. DOI: 10.1155/2013/903172.
Methadone-induced hypoglycemia.
Faskowitz A, Kramskiy V, Pasternak G Cell Mol Neurobiol. 2013; 33(4):537-42.
PMID: 23467779 PMC: 3622167. DOI: 10.1007/s10571-013-9919-6.
Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
George M, Kitzmiller J, Ewald M, ODonell K, Becter M, Salhanick S J Med Toxicol. 2012; 8(4):432-5.
PMID: 22898875 PMC: 3550268. DOI: 10.1007/s13181-012-0249-8.
The relationship between opioid and sugar intake: review of evidence and clinical applications.
Mysels D, Sullivan M J Opioid Manag. 2011; 6(6):445-52.
PMID: 21269006 PMC: 3109725. DOI: 10.5055/jom.2010.0043.