Mucin Overproduction in Chronic Inflammatory Lung Disease

Overview

Journal Can Respir J

Publisher Wiley

Specialty Pulmonary Medicine

Date 2006 Sep 20

PMID 16983448

Citations 33

Authors

Hans-Peter Hauber

Susan C Foley

Qutayba Hamid

Affiliations

Soon will be listed here.

Abstract

Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.

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