LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release

Overview

Journal Science

Specialty Science

Date 1990 Sep 14

PMID 1697984

Citations 55

Authors

D S Webb

Y Shimizu

G A van Seventer

S Shaw

T L Gerrard

Affiliations

Soon will be listed here.

Abstract

The monocyte-derived cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), are central regulators of the immune response, but the physiologic stimuli for their release remain largely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-alpha and IL-1 beta release. In addition, TNF-alpha was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.

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