Association of Estrogen Receptor Alpha Gene Polymorphisms and Lifestyle Factors with Calcaneal Quantitative Ultrasound and Osteoporosis in Postmenopausal Vietnamese Women

Overview

Journal J Hum Genet

Specialty Genetics

Date 2006 Sep 15

PMID 16972020

Citations 2

Authors

Tran Quang Binh

Toshikatsu Shinka

Nguyen Cong Khan

Vu Thi Thu Hien

Nguyen Thi Lam

Le Bach Mai

Takuro Nakano

Masako Sei

Shigeru Yamamoto

Masayo Nakamori

Yutaka Nakahori

Affiliations

Soon will be listed here.

Abstract

Genetic and lifestyle factors are important in the pathogenesis of osteoporosis. We investigated the relationships of PvuII and XbaI polymorphisms of the estrogen receptor alpha (ER-alpha) gene, lifestyle factors with speed of sound at the calcaneus (calcaneal SOS) and osteoporosis in a population-based study of 140 healthy postmenopausal women. By an analysis of covariates, women with higher copies of P or X alleles had higher calcaneal SOS compared with others (P=0.012, PP vs. pp; P=0.045, Xx vs. xx). Women with lower copies of px or higher copies of PX haplotypes had higher calcaneal SOS compared with others (P=0.021, 0 px vs. 2 px; P=0.011, 1 PX vs. 0 PX). The px and PX haplotypes, age and years since menopause were found to be independent predictors of calcaneal SOS in multiple linear regression models. Using logistic regression, we found an increased osteoporosis risk with evidence for a px haplotype dose effect (OR=2.82, 95% CI=1.50-5.31, P=0.001) and for a PX haplotype dose effect (OR=0.42, 95% CI=0.19-0.93, P=0.033). An increased educational level was associated with a reduced risk of osteoporosis (P=0.035 in the model with px, P=0.044 in the model with PX). In conclusion, the present study suggests that PvuII and XbaI polymorphims of the ER-alpha gene, age, years since menopause and educational level are associated with bone density, as assessed by calcaneal SOS, and osteoporosis in postmenopausal Vietnamese women.

Citing Articles

Association study of estrogen receptor alpha gene polymorphisms with bone mass assessed by quantitative ultrasound in young adults.

Correa-Rodriguez M, Schmidt-RioValle J, Rueda-Medina B Rheumatol Int. 2017; 37(8):1281-1286.

PMID: 28534210 DOI: 10.1007/s00296-017-3748-8.

Correlations between genetic variance and adiposity measures, and gene x gene interactions for obesity in postmenopausal Vietnamese women.

Binh T, Nakahori Y, Hien V, Khan N, Lam N, Mai L J Genet. 2011; 90(1):1-9.

PMID: 21677383

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