Ameliorating Role of Caffeic Acid Phenethyl Ester (CAPE) Against Isoniazid-induced Oxidative Damage in Red Blood Cells

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2006 Sep 12

PMID 16964438

Citations 5

Authors

Osman Gokalp

Efkan Uz

Ekrem Cicek

H Ramazan Yilmaz

Mehmet Kaya Ozer

Ayse Altunbas

Nurten Ozcelik

Affiliations

Soon will be listed here.

Abstract

Isoniazid (INH) still remains a first-line drug both for treatment and prophylaxis of tuberculosis, but various organs toxicity frequently develops in patients receiving this drug. We aimed to investigate possible toxic effects of INH on rat red blood cells (RBCs), and to elucidate whether Caffeic acid phenethyl ester (CAPE) prevents a possible toxic effect of INH. Experimental groups were designed as follows: control group, INH group, INH + CAPE group. Compared with the control, the INH caused a significant increase in superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels, and a decrease in glutathione peroxidase (GSH-Px) and catalase (CAT), which are recently used to monitor the development and extent of damage due to oxidative stresses. CAPE administration to INH group ameliorated above changes due to INH.

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