Genetic Influences on the Retention of Inorganic Mercury

Overview

Journal Arch Environ Occup Health

Specialties Environmental Health
Occupational Medicine

Date 2006 Sep 12

PMID 16961004

Citations 28

Authors

Hipolito M Custodio

Raul Harari

Lars Gerhardsson

Staffan Skerfving

Karin Broberg

Affiliations

Soon will be listed here.

Abstract

Mercury is eliminated as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL), and conjugation by glutathione S-transferases (GST). This study tested if polymorphisms in GCL and GST genes modify mercury retention in humans exposed to elemental mercury vapor. Total mercury concentrations in whole blood, plasma and urine, and genotypes for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 309 gold miners, gold buyers and controls. The presence of the GCLM-588T allele was associated with increased blood, plasma and urine mercury levels. These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury.

Citing Articles

Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.

Zaman S, Samms-Vaughan M, Saroukhani S, Bressler J, Hessabi M, Grove M BMC Pediatr. 2024; 24(1):14.

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Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children.

Rahbar M, Samms-Vaughan M, Zhao Y, Saroukhani S, Bressler J, Hessabi M Genes (Basel). 2022; 13(10).

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Gene Variants Determine Placental Transfer of Perfluoroalkyl Substances (PFAS), Mercury (Hg) and Lead (Pb), and Birth Outcome: Findings From the UmMuKi Bratislava-Vienna Study.

Gundacker C, Graf-Rohrmeister K, Gencik M, Hengstschlager M, Holoman K, Rosa P Front Genet. 2021; 12:664946.

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Medina Perez O, Florez-Vargas O, Rincon Cruz G, Rondon Gonzalez F, Rocha Munoz L, Sanchez Rodriguez L Sci Rep. 2021; 11(1):8716.

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Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet.

Wahlberg K, Love T, Pineda D, Engstrom K, Watson G, Thurston S Environ Int. 2018; 115:142-149.

PMID: 29573653 PMC: 5970067. DOI: 10.1016/j.envint.2018.03.015.