DHEAS Levels and Mortality in Disabled Older Women: the Women's Health and Aging Study I

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2006 Sep 9

PMID 16960027

Citations 26

Authors

Anne R Cappola

Qian-Li Xue

Jeremy D Walston

Sean X Leng

Luigi Ferrucci

Jack Guralnik

Linda P Fried

Affiliations

Soon will be listed here.

Abstract

Background: Dehydroepiandrosterone sulfate (DHEAS) is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects. Low DHEAS levels are associated with mortality in older men, but the relationship between DHEAS levels and mortality in women is not clearly defined.

Methods: The relationship between serum DHEAS level and 5-year mortality was analyzed in a cohort of 539 disabled women aged 65-100 years enrolled in the Women's Health and Aging Study I (WHAS I). Using Cox proportional hazard models, we calculated multivariate-adjusted mortality risks by DHEAS quartiles and by DHEAS continuously, allowing for a nonlinear relationship. We also examined cause-specific mortality.

Results: We found a U-shaped relationship between DHEAS level and mortality. After adjusting for multiple covariates, women in the top and bottom DHEAS quartiles had a more than 2-fold higher 5-year mortality than did those in the middle quartiles (hazard ratio, 2.15; 95% confidence interval [CI], 1.17-3.98 for the top quartile and 2.05; 95% CI, 1.27-3.32 for the bottom quartile, each compared to the third quartile). Women with higher DHEAS levels tended to have greater cancer mortality, whereas those with lower DHEAS tended to have greater cardiovascular mortality.

Conclusion: Disabled older women with either low or high levels of DHEAS are at greater risk for death than are those with intermediate levels. More research is needed to determine if targeted dehydroepiandrosterone supplementation would provide clinical benefit to disabled older women.

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References

Longcope C . Metabolism of dehydroepiandrosterone. Ann N Y Acad Sci. 1995; 774:143-8. DOI: 10.1111/j.1749-6632.1995.tb17378.x. View

Barrett-Connor E, Edelstein S . A prospective study of dehydroepiandrosterone sulfate and cognitive function in an older population: the Rancho Bernardo Study. J Am Geriatr Soc. 1994; 42(4):420-3. DOI: 10.1111/j.1532-5415.1994.tb07491.x. View

Berr C, Lafont S, Debuire B, Dartigues J, Baulieu E . Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study. Proc Natl Acad Sci U S A. 1996; 93(23):13410-5. PMC: 24107. DOI: 10.1073/pnas.93.23.13410. View

Nafziger A, Bowlin S, Jenkins P, PEARSON T . Longitudinal changes in dehydroepiandrosterone concentrations in men and women. J Lab Clin Med. 1998; 131(4):316-23. DOI: 10.1016/s0022-2143(98)90181-0. View

Parasrampuria J, Schwartz K, Petesch R . Quality control of dehydroepiandrosterone dietary supplement products. JAMA. 1998; 280(18):1565. DOI: 10.1001/jama.280.18.1565. View

Tilvis R, Kahonen M, HARKONEN M . Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population. Aging (Milano). 1999; 11(1):30-4. View

Barrett-Connor E, von Muhlen D, Laughlin G, Kripke A . Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo Study. J Am Geriatr Soc. 1999; 47(6):685-91. DOI: 10.1111/j.1532-5415.1999.tb01590.x. View

Villareal D, Holloszy J . Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004; 292(18):2243-8. DOI: 10.1001/jama.292.18.2243. View

Labrie F . Adrenal androgens and intracrinology. Semin Reprod Med. 2005; 22(4):299-309. DOI: 10.1055/s-2004-861547. View

10.

Maggio M, Ceda G, De Cicco G, Cattadori E, Visioli S, Ablondi F . Acute changes in circulating hormones in older patients with impaired ventricular function undergoing on-pump coronary artery bypass grafting. J Endocrinol Invest. 2005; 28(8):711-9. DOI: 10.1007/BF03347554. View

11.

Thomas G, Frenoy N, Legrain S, Baulieu E, Debuire B . Serum dehydroepiandrosterone sulfate levels as an individual marker. J Clin Endocrinol Metab. 1994; 79(5):1273-6. DOI: 10.1210/jcem.79.5.7962319. View

12.

Kasper J, Shapiro S, Guralnik J, Bandeen-Roche K, Fried L . Designing a community study of moderately to severely disabled older women: the Women's Health and Aging Study. Ann Epidemiol. 1999; 9(8):498-507. DOI: 10.1016/s1047-2797(99)00026-5. View

13.

Baulieu E, Thomas G, Legrain S, Lahlou N, Roger M, Debuire B . Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A. 2000; 97(8):4279-84. PMC: 18228. DOI: 10.1073/pnas.97.8.4279. View

14.

Hall C, Lipton R, Sliwinski M, Stewart W . A change point model for estimating the onset of cognitive decline in preclinical Alzheimer's disease. Stat Med. 2000; 19(11-12):1555-66. DOI: 10.1002/(sici)1097-0258(20000615/30)19:11/12<1555::aid-sim445>3.0.co;2-3. View

15.

Laughlin G, Barrett-Connor E . Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. J Clin Endocrinol Metab. 2000; 85(10):3561-8. DOI: 10.1210/jcem.85.10.6861. View

16.

Kahonen M, Tilvis R, Jolkkonen J, Pitkala K, HARKONEN M . Predictors and clinical significance of declining plasma dehydroepiandrosterone sulfate in old age. Aging (Milano). 2000; 12(4):308-14. DOI: 10.1007/BF03339852. View

17.

Mazat L, Lafont S, Berr C, Debuire B, Tessier J, Dartigues J . Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci U S A. 2001; 98(14):8145-50. PMC: 35482. DOI: 10.1073/pnas.121177998. View

18.

Yen S . Dehydroepiandrosterone sulfate and longevity: new clues for an old friend. Proc Natl Acad Sci U S A. 2001; 98(15):8167-9. PMC: 37415. DOI: 10.1073/pnas.161278698. View

19.

Cappola A, Bandeen-Roche K, Wand G, Volpato S, Fried L . Association of IGF-I levels with muscle strength and mobility in older women. J Clin Endocrinol Metab. 2001; 86(9):4139-46. DOI: 10.1210/jcem.86.9.7868. View

20.

Trivedi D, Khaw K . Dehydroepiandrosterone sulfate and mortality in elderly men and women. J Clin Endocrinol Metab. 2001; 86(9):4171-7. DOI: 10.1210/jcem.86.9.7838. View