Genetics of Streptomyces Rimosus, the Oxytetracycline Producer

Overview

Journal Microbiol Mol Biol Rev

Publisher American Society for Microbiology

Specialty Microbiology

Date 2006 Sep 9

PMID 16959966

Citations 41

Authors

Hrvoje Petkovic

John Cullum

Daslav Hranueli

Iain S Hunter

Natasa Peric-Concha

Jasenka Pigac

Arinthip Thamchaipenet

Dusica Vujaklija

Paul F Long

Affiliations

Soon will be listed here.

Abstract

From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and noninfective diseases. Procedures for in vivo and in vitro genetic manipulations in S. rimosus have been developed since the 1950s and applied to study the genetic instability of S. rimosus strains and for the molecular cloning and characterization of genes involved in oxytetracycline biosynthesis. Recent advances in the methodology of genome sequencing bring the realistic prospect of obtaining the genome sequence of S. rimosus in the near term.

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References

deWitt J . Evidence for a sex factor in Streptomyces erythreus. J Bacteriol. 1985; 164(2):969-71. PMC: 214354. DOI: 10.1128/jb.164.2.969-971.1985. View

Plohl M, Gamulin V . Five transfer RNA genes lacking CCA termini are clustered in the chromosome of Streptomyces rimosus. Mol Gen Genet. 1990; 222(1):129-34. DOI: 10.1007/BF00283033. View

Nussbaumer B, Wohlleben W . Identification, isolation and sequencing of the recA gene of Streptomyces lividans TK24. FEMS Microbiol Lett. 1994; 118(1-2):57-63. DOI: 10.1111/j.1574-6968.1994.tb06803.x. View

Ahel I, Mikoc A, Gamulin V . recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein. FEMS Microbiol Lett. 2005; 248(1):119-24. DOI: 10.1016/j.femsle.2005.05.030. View

Peric-Concha N, Borovicka B, Long P, Hranueli D, Waterman P, Hunter I . Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length. J Biol Chem. 2005; 280(45):37455-60. DOI: 10.1074/jbc.M503191200. View

Randazzo R, Sermonti G, CARERE A, Bignami M . Comutation in Streptomyces. J Bacteriol. 1973; 113(1):500-1. PMC: 251653. DOI: 10.1128/jb.113.1.500-501.1973. View

MacNeil D . Characterization of a unique methyl-specific restriction system in Streptomyces avermitilis. J Bacteriol. 1988; 170(12):5607-12. PMC: 211658. DOI: 10.1128/jb.170.12.5607-5612.1988. View

RAUTENSHTEIN I, Zhunaeva V, KHOKHLOVA I, Nesterova N, Moskalenko L . [Factors causing lysis of an Actinomyces rimosus culture, the producer of the antibiotic, oxytetracycline]. Mikrobiologiia. 1975; 44(5):899-904. View

Sowinski P, Pawlak J, Borowski E, Gariboldi P . Stereostructure of Rimocidin. J Antibiot (Tokyo). 1995; 48(11):1288-91. DOI: 10.7164/antibiotics.48.1288. View

10.

ALIKHANIAN S, Mindlin S . Recombinations in Streptomyces rimosus. Nature. 1957; 180(4596):1208-9. DOI: 10.1038/1801208a0. View

11.

Lee S, Omer C, Brasch M, Cohen S . Analysis of recombination occurring at SLP1 att sites. J Bacteriol. 1988; 170(12):5806-13. PMC: 211686. DOI: 10.1128/jb.170.12.5806-5813.1988. View

12.

Yao W, VINING L . Cloning and sequence analysis of a recA-like gene from Streptomyces venezuelae ISP5230. FEMS Microbiol Lett. 1994; 118(1-2):51-6. DOI: 10.1111/j.1574-6968.1994.tb06802.x. View

13.

Reynes J, Calmels T, Drocourt D, Tiraby G . Cloning, expression in Escherichia coli and nucleotide sequence of a tetracycline-resistance gene from Streptomyces rimosus. J Gen Microbiol. 1988; 134(3):585-98. DOI: 10.1099/00221287-134-3-585. View

14.

Berdy J . Bioactive microbial metabolites. J Antibiot (Tokyo). 2005; 58(1):1-26. DOI: 10.1038/ja.2005.1. View

15.

Summers R, Wendt-Pienkowski E, Motamedi H, Hutchinson C . Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase. J Bacteriol. 1992; 174(6):1810-20. PMC: 205782. DOI: 10.1128/jb.174.6.1810-1820.1992. View

16.

Huang C, Lin Y, Yang Y, Huang S, Chen C . The telomeres of Streptomyces chromosomes contain conserved palindromic sequences with potential to form complex secondary structures. Mol Microbiol. 1998; 28(5):905-16. DOI: 10.1046/j.1365-2958.1998.00856.x. View

17.

Gravius B, Bezmalinovic T, Hranueli D, Cullum J . Genetic instability and strain degeneration in Streptomyces rimosus. Appl Environ Microbiol. 1993; 59(7):2220-8. PMC: 182261. DOI: 10.1128/aem.59.7.2220-2228.1993. View

18.

Elizarov S, Sergienko O, Sizova I, Danilenko V . [Dependence of aminoglycoside 3'-phosphotransferase VIII activity on protein serine/threonine kinases in Streptomyces rimosus]. Mol Biol (Mosk). 2005; 39(2):255-63. View

19.

Gravius B, Glocker D, Pigac J, Pandza K, Hranueli D, Cullum J . The 387 kb linear plasmid pPZG101 of Streptomyces rimosus and its interactions with the chromosome. Microbiology (Reading). 1994; 140 ( Pt 9):2271-7. DOI: 10.1099/13500872-140-9-2271. View

20.

Gamulin V, Soll D . The initiator tRNA genes from Streptomyces rimosus. Nucleic Acids Res. 1987; 15(16):6747. PMC: 306148. DOI: 10.1093/nar/15.16.6747. View