RDMAS: a Web Server for RNA Deleterious Mutation Analysis

Overview

Journal BMC Bioinformatics

Publisher Biomed Central

Specialty Biology

Date 2006 Sep 8

PMID 16956394

Citations 19

Authors

Wenjie Shu

Xiaochen Bo

Rujia Liu

Dongsheng Zhao

Zhiqiang Zheng

Shengqi Wang

Affiliations

Soon will be listed here.

Abstract

Background: The diverse functions of ncRNAs critically depend on their structures. Mutations in ncRNAs disrupting the structures of functional sites are expected to be deleterious. RNA deleterious mutations have attracted wide attentions because some of them in cells result in serious disease, and some others in microbes influence their fitness.

Results: The RDMAS web server we describe here is an online tool for evaluating structural deleteriousness of single nucleotide mutation in RNA genes. Several structure comparison methods have been integrated; sub-optimal structures predicted can be optionally involved to mitigate the uncertainty of secondary structure prediction. With a user-friendly interface, the web application is easy to use. Intuitive illustrations are provided along with the original computational results to facilitate quick analysis.

Conclusion: RDMAS can be used to explore the structure alterations which cause mutations pathogenic, and to predict deleterious mutations which may help to determine the functionally critical regions. RDMAS is freely accessed via http://biosrv1.bmi.ac.cn/rdmas.

Citing Articles

IndelsRNAmute: predicting deleterious multiple point substitutions and indels mutations.

Churkin A, Ponty Y, Barash D BMC Bioinformatics. 2022; 23(Suppl 8):424.

PMID: 36241988 PMC: 9569039. DOI: 10.1186/s12859-022-04943-0.

Central Precocious Puberty Caused by Novel Mutations in the Promoter and 5'-UTR Region of the Imprinted Gene.

Fanis P, Skordis N, Toumba M, Papaioannou N, Makris A, Kyriakou A Front Endocrinol (Lausanne). 2019; 10:677.

PMID: 31636607 PMC: 6787840. DOI: 10.3389/fendo.2019.00677.

SSS-test: a novel test for detecting positive selection on RNA secondary structure.

Walter Costa M, Honer Zu Siederdissen C, Dunjic M, Stadler P, Nowick K BMC Bioinformatics. 2019; 20(1):151.

PMID: 30898084 PMC: 6429701. DOI: 10.1186/s12859-019-2711-y.

SilentMutations (SIM): A tool for analyzing long-range RNA-RNA interactions in viral genomes and structured RNAs.

Desiro D, Holzer M, Ibrahim B, Marz M Virus Res. 2018; 260:135-141.

PMID: 30439394 PMC: 7172452. DOI: 10.1016/j.virusres.2018.11.005.

Variations in the 3'UTR of the Gene in Heterozygous Females with Hyperandrogenaemia.

Neocleous V, Fanis P, Toumba M, Phedonos A, Picolos M, Andreou E Int J Endocrinol. 2017; 2017:8984365.

PMID: 28487735 PMC: 5405599. DOI: 10.1155/2017/8984365.

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