The DbpBA Locus of Borrelia Burgdorferi is Not Essential for Infection of Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2006 Sep 7

PMID 16954404

Citations 25

Authors

Yanlin Shi

Qilong Xu

Sunita V Seemanapalli

Kristy McShan

Fang Ting Liang

Affiliations

Soon will be listed here.

Abstract

The Lyme disease spirochete Borrelia burgdorferi expresses a broad array of adhesive molecules, including the decorin-binding proteins A and B (DbpA and DbpB), which are believed to play important roles in mammalian infection. The dbpBA locus was deleted; resulting mutants were able to infect both immunodeficient and immunocompetent mice, indicating that neither DbpA nor DbpB is essential for the infection of mammals, although the DbpAB deficiency may significantly attenuate infectivity potential.

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