Digital X-ray Radiogrammetry Better Identifies Osteoarthritis Patients with a Low Bone Mineral Density Than Quantitative Ultrasound

Overview

Journal Eur Radiol

Specialty Radiology

Date 2006 Sep 6

PMID 16953374

Authors

Gerhard W Goerres

Diana Frey

Thomas F Hany

Burkhardt Seifert

Hans Jorg Hauselmann

Annina Studer

Dagmar Hauser

Nathalie Zilic

Beat A Michel

Didier Hans

Daniel Uebelhart

Affiliations

Soon will be listed here.

Abstract

This study assessed the ability of quantitative ultrasound (QUS) and digital X-ray radiogrammetry (DXR) to identify osteopenia and osteoporosis in patients with knee osteoarthritis (OA). One hundred and sixty-one patients with painful knee OA (81 men, 80 women; age 62.6+/-9.2 years, range 40-82 years) were included in this cross-sectional study and underwent dual-energy X-ray absorptiometry (DXA) of both hips and the lumbar spine, QUS of the phalanges and calcanei of both hands and heels, and DXR using radiographs of both hands. Unpaired t-test, Mann-Whitney U test, ROC analysis and Spearman's rank correlation were used for comparisons and correlation of methods. Using DXA as the reference standard, we defined a low bone mineral density (BMD) as a T-score < or =-1.0 at the lumbar spine or proximal femur. In contrast to phalangeal or calcaneal QUS, DXR was able to discriminate patients with a low BMD at the lumbar spine (p<0.0001) or hips (p<0.0001). ROC analysis showed that DXR had an acceptable predictive power in identifying OA patients a low hip BMD (sensitivity 70%, specificity 71%). Therefore, DXR used as a screening tool could help in identifying patients with knee OA for DXA.

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