Catalytic Enantioselective Decarboxylative Protonation

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2006 Aug 31

PMID 16939246

Citations 38

Authors

Justin T Mohr

Toyoki Nishimata

Douglas C Behenna

Brian M Stoltz

Affiliations

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Abstract

We report a highly enantioselective, general catalytic system for the facile synthesis of tertiary stereocenters by protonation adjacent to cyclic ketones. The method relies on catalytic decarboxylative protonation of readily accessible racemic quaternary beta-ketoesters. A range of substituted cycloalkanone compounds can be accessed through this process with high levels of enantioselectivity.

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