Intestinal Mucosal Adaptation

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2006 Aug 29

PMID 16937429

Citations 29

Authors

Laurie Drozdowski

Alan B R Thomson

Affiliations

Soon will be listed here.

Abstract

Intestinal failure is a condition characterized by malnutrition and/or dehydration as a result of the inadequate digestion and absorption of nutrients. The most common cause of intestinal failure is short bowel syndrome, which occurs when the functional gut mass is reduced below the level necessary for adequate nutrient and water absorption. This condition may be congenital, or may be acquired as a result of a massive resection of the small bowel. Following resection, the intestine is capable of adaptation in response to enteral nutrients as well as other trophic stimuli. Identifying factors that may enhance the process of intestinal adaptation is an exciting area of research with important potential clinical applications.

Citing Articles

Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders.

Cerdo T, Garcia-Santos J, Rodriguez-Pohnlein A, Garcia-Ricobaraza M, Nieto-Ruiz A, Bermudez M Nutrients. 2022; 14(21).

PMID: 36364953 PMC: 9658482. DOI: 10.3390/nu14214691.

Tissue Homeostasis and Non-Homeostasis: From Cell Life Cycles to Organ States.

OBrien L Annu Rev Cell Dev Biol. 2022; 38:395-418.

PMID: 35850152 PMC: 10182861. DOI: 10.1146/annurev-cellbio-120420-114855.

Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention?.

Seijo M, Bonanno M, Bryk G, Zeni Coronel M, Pita Martin de Portela M, Zeni S Calcif Tissue Int. 2022; 111(3):300-312.

PMID: 35505249 DOI: 10.1007/s00223-022-00984-y.

Jejunal transcriptomic profiling of two layer strains throughout the entire production period.

Omotoso A, Reyer H, Oster M, Ponsuksili S, Trakooljul N, Murani E Sci Rep. 2021; 11(1):20086.

PMID: 34635722 PMC: 8505660. DOI: 10.1038/s41598-021-99566-5.

MicroRNA expression profiling during the suckling-to-weaning transition in pigs.

Jang H, Lee S J Anim Sci Technol. 2021; 63(4):854-863.

PMID: 34447961 PMC: 8367414. DOI: 10.5187/jast.2021.e69.

References

Meddings J, Theisen S . Development of rat jejunum: lipid permeability, physical properties, and chemical composition. Am J Physiol. 1989; 256(5 Pt 1):G931-40. DOI: 10.1152/ajpgi.1989.256.5.G931. View

Hosoda N, Nishi M, Nakagawa M, Hiramatsu Y, Hioki K, Yamamoto M . Structural and functional alterations in the gut of parenterally or enterally fed rats. J Surg Res. 1989; 47(2):129-33. DOI: 10.1016/0022-4804(89)90076-0. View

Meddings J . Lipid permeability of the intestinal microvillus membrane may be modulated by membrane fluidity in the rat. Biochim Biophys Acta. 1989; 984(2):158-66. DOI: 10.1016/0005-2736(89)90211-3. View

Lobie P, Breipohl W, Waters M . Growth hormone receptor expression in the rat gastrointestinal tract. Endocrinology. 1990; 126(1):299-306. DOI: 10.1210/endo-126-1-299. View

Thomson A, Keelan M, Clandinin M . Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. Biochim Biophys Acta. 1991; 1084(2):122-8. DOI: 10.1016/0005-2760(91)90210-9. View

Cheeseman C, Harley B . Adaptation of glucose transport across rat enterocyte basolateral membrane in response to altered dietary carbohydrate intake. J Physiol. 1991; 437:563-75. PMC: 1180063. DOI: 10.1113/jphysiol.1991.sp018611. View

Fedorak R, Cheeseman C, Thomson A, Porter V . Altered glucose carrier expression: mechanism of intestinal adaptation during streptozocin-induced diabetes in rats. Am J Physiol. 1991; 261(4 Pt 1):G585-91. DOI: 10.1152/ajpgi.1991.261.4.G585. View

Meddings J, Gall D . Epidermal growth factor and postnatal development of intestinal transport and membrane structure. Pediatr Res. 1991; 30(4):342-50. DOI: 10.1203/00006450-199110000-00010. View

Keelan M, Wierzbicki A, Clandinin M, Walker K, Thomson A . Alterations in dietary fatty acid composition alter rat brush border membrane phospholipid fatty acid composition. Diabetes Res. 1990; 14(4):165-70. View

10.

Ferraris R, Diamond J . Crypt-villus site of glucose transporter induction by dietary carbohydrate in mouse intestine. Am J Physiol. 1992; 262(6 Pt 1):G1069-73. DOI: 10.1152/ajpgi.1992.262.6.G1069. View

11.

Rountree D, Ulshen M, Selub S, Fuller C, Bloom S, Ghatei M . Nutrient-independent increases in proglucagon and ornithine decarboxylase messenger RNAs after jejunoileal resection. Gastroenterology. 1992; 103(2):462-8. DOI: 10.1016/0016-5085(92)90835-m. View

12.

Ulshen M, Dowling R, Fuller C, Zimmermann E, Lund P . Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. Gastroenterology. 1993; 104(4):973-80. DOI: 10.1016/0016-5085(93)90263-c. View

13.

Tamada H, Nezu R, Matsuo Y, IMAMURA I, Takagi Y, Okada A . Alanyl glutamine-enriched total parenteral nutrition restores intestinal adaptation after either proximal or distal massive resection in rats. JPEN J Parenter Enteral Nutr. 1993; 17(3):236-42. DOI: 10.1177/0148607193017003236. View

14.

Rand E, Depaoli A, Davidson N, Bell G, Burant C . Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5. Am J Physiol. 1993; 264(6 Pt 1):G1169-76. DOI: 10.1152/ajpgi.1993.264.6.G1169. View

15.

Diamond J . Evolutionary physiology. Quantitative design of life. Nature. 1993; 366(6454):405-6. DOI: 10.1038/366405a0. View

16.

Sugawara S, Takeda K, Lee A, Dennert G . Suppression of stress protein GRP78 induction in tumor B/C10ME eliminates resistance to cell mediated cytotoxicity. Cancer Res. 1993; 53(24):6001-5. View

17.

Potten C, Merritt A, Hickman J, Hall P, Faranda A . Characterization of radiation-induced apoptosis in the small intestine and its biological implications. Int J Radiat Biol. 1994; 65(1):71-8. DOI: 10.1080/09553009414550101. View

18.

Burant C, Flink S, Depaoli A, Chen J, Lee W, Hediger M . Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes. J Clin Invest. 1994; 93(2):578-85. PMC: 293881. DOI: 10.1172/JCI117010. View

19.

Thomson A, Cheeseman C, Keelan M, Fedorak R, Clandinin M . Crypt cell production rate, enterocyte turnover time and appearance of transport along the jejunal villus of the rat. Biochim Biophys Acta. 1994; 1191(1):197-204. DOI: 10.1016/0005-2736(94)90249-6. View

20.

Thissen J, Ketelslegers J, Underwood L . Nutritional regulation of the insulin-like growth factors. Endocr Rev. 1994; 15(1):80-101. DOI: 10.1210/edrv-15-1-80. View