Mucormycosis Resulting in Gastric Perforation in a Patient with Acute Myelogenous Leukemia: Report of a Case

Overview

Journal Surg Today

Specialty General Surgery

Date 2006 Aug 29

PMID 16937290

Citations 4

Authors

Kyo Young Song

Won Kyung Kang

Chong Won Park

Yeong Jin Choi

Sung Eun Rha

Cho Hyun Park

Affiliations

Soon will be listed here.

Abstract

Mucormycosis is an uncommon opportunistic fungal infection that may develop in immunocompromised patients with conditions such as diabetes mellitus, leukemia, lymphoma, or human immunodeficiency virus (HIV), or after transplantation with immunosupperessive therapy. We report a case of gastric perforation caused by a mucormycosis infection in a patient with acute myelogenous leukemia (AML). The patient was treated successfully with gastrectomy and the aggressive use of intravenous amphotericin B. He is still alive 1 year after his operation.

Citing Articles

Gastric Perforation Secondary to Fungal Gastritis in an Immuno-Competent Adult.

Rai A, Gajula B, Kumar N, Malik A Cureus. 2021; 13(2):e13156.

PMID: 33692925 PMC: 7937405. DOI: 10.7759/cureus.13156.

Total Gastric Necrosis Due to Mucormycosis: A Rare Case of Gastric Perforation.

Termos S, Othman F, Alali M, Al Bader B, AlKhadher T, Hassanaiah W Am J Case Rep. 2018; 19:527-533.

PMID: 29724988 PMC: 5956728. DOI: 10.12659/AJCR.908952.

Combination liposomal amphotericin B, posaconazole and oral amphotericin B for treatment of gastrointestinal in an immunocompromised patient.

Anderson A, McManus D, Perreault S, Lo Y, Seropian S, Topal J Med Mycol Case Rep. 2017; 17:11-13.

PMID: 28580237 PMC: 5447657. DOI: 10.1016/j.mmcr.2017.05.004.

A patient with neutropenic fever and abdominal pain showing absent bowel wall on CT.

Kim H, Rha S, Kang W Br J Radiol. 2011; 84(1001):478-80.

PMID: 21511752 PMC: 3473660. DOI: 10.1259/bjr/13586512.

References

Lyon D, Schubert T, Mantia A, Kaplan M . Phycomycosis of the gastrointestinal tract. Am J Gastroenterol. 1979; 72(4):379-94. View

Kumar A, Khilnani G, Aggarwal S, Kumar S, Banerjee U, Xess I . Primary cutaneous mucormycosis in an immunocompetent host: report of a case. Surg Today. 2003; 33(4):319-22. DOI: 10.1007/s005950300073. View

DEAL W, Johnson 3rd J . Gastric phycomycosis. Report of a case and review of the literature. Gastroenterology. 1969; 57(5):579-86. View

Lawson H, SCHMAMAN A . Gastric phycomycosis. Br J Surg. 1974; 61(9):743-6. DOI: 10.1002/bjs.1800610918. View

Cherney C, Chutuape A, Fikrig M . Fatal invasive gastric mucormycosis occurring with emphysematous gastritis: case report and literature review. Am J Gastroenterol. 1999; 94(1):252-6. DOI: 10.1111/j.1572-0241.1999.00809.x. View

Husain S, Alexander B, Munoz P, Avery R, Houston S, Pruett T . Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi. Clin Infect Dis. 2003; 37(2):221-9. DOI: 10.1086/375822. View

Ng T, Denning D . Liposomal amphotericin B (AmBisome) therapy in invasive fungal infections. Evaluation of United Kingdom compassionate use data. Arch Intern Med. 1995; 155(10):1093-8. View

Ribes J, Baker D . Zygomycetes in human disease. Clin Microbiol Rev. 2001; 13(2):236-301. PMC: 100153. DOI: 10.1128/CMR.13.2.236. View

Mondy K, Haughey B, Custer P, Wippold 2nd F, Ritchie D, Mundy L . Rhinocerebral mucormycosis in the era of lipid-based amphotericin B: case report and literature review. Pharmacotherapy. 2002; 22(4):519-26. DOI: 10.1592/phco.22.7.519.33679. View

10.

Pagano L, Offidani M, Fianchi L, Nosari A, Candoni A, Picardi M . Mucormycosis in hematologic patients. Haematologica. 2004; 89(2):207-14. View

11.

Bohme A, Ruhnke M, Buchheidt D, Karthaus M, Einsele H, Guth S . Treatment of fungal infections in hematology and oncology--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 2003; 82 Suppl 2:S133-40. DOI: 10.1007/s00277-003-0767-1. View

12.

Al-Abbadi M, Russo K, Wilkinson E . Pulmonary mucormycosis diagnosed by bronchoalveolar lavage: a case report and review of the literature. Pediatr Pulmonol. 1997; 23(3):222-5. DOI: 10.1002/(sici)1099-0496(199703)23:3<222::aid-ppul9>3.0.co;2-p. View

13.

Hosseini M, Lee J . Gastrointestinal mucormycosis mimicking ischemic colitis in a patient with systemic lupus erythematosus. Am J Gastroenterol. 1998; 93(8):1360-2. DOI: 10.1111/j.1572-0241.1998.00417.x. View

14.

Ingram C, Sennesh J, Cooper J, Perfect J . Disseminated zygomycosis: report of four cases and review. Rev Infect Dis. 1989; 11(5):741-54. DOI: 10.1093/clinids/11.5.741. View

15.

Heinemann V, Bosse D, Jehn U, Kahny B, Wachholz K, Debus A . Pharmacokinetics of liposomal amphotericin B (Ambisome) in critically ill patients. Antimicrob Agents Chemother. 1997; 41(6):1275-80. PMC: 163899. DOI: 10.1128/AAC.41.6.1275. View

16.

Agger W, Maki D . Mucormycosis. A complication of critical care. Arch Intern Med. 1978; 138(6):925-7. DOI: 10.1001/archinte.138.6.925. View

17.

Parfrey N . Improved diagnosis and prognosis of mucormycosis. A clinicopathologic study of 33 cases. Medicine (Baltimore). 1986; 65(2):113-23. DOI: 10.1097/00005792-198603000-00004. View

18.

Boucher H, Groll A, Chiou C, Walsh T . Newer systemic antifungal agents : pharmacokinetics, safety and efficacy. Drugs. 2004; 64(18):1997-2020. DOI: 10.2165/00003495-200464180-00001. View