Incidence of and Risk Factors for Dysplasia in Mucosectomy Area in Ulcerative Colitis Patients Undergoing Restorative Proctocolectomy

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2006 Aug 29

PMID 16937110

Citations 5

Authors

Ken Sagayama

Hiroki Ikeuchi

Takashi Nishigami

Hiroki Nakano

Motoi Uchino

Mitsuhiro Nakamura

Masafumi Noda

Hidenori Yanagi

Takehira Yamamura

Affiliations

Soon will be listed here.

Abstract

Background And Aims: We evaluated the incidence of dysplasia in the mucosectomy area using resected specimens to determine preoperative risk factors for the occurrence of dysplasia in this area.

Patients And Methods: We prospectively studied a consecutive series of 137 patients, each of whom underwent a restorative proctocolectomy with a mucosectomy and hand-sewn ileal J-pouch anal anastomosis between January 2003 and December 2004. Sections from the anal transitional zone mucosa were taken from the dentate line to 2.5 cm above the resected line and stained with hematoxylin and eosin then characterized as indefinite for dysplasia, low-grade dysplasia, and high-grade dysplasia based on the criteria of an international working group for rectal mucosal atypia.

Results: Dysplasia of the mucosectomy area was present in six (4.4%) of the patients, including one with low-grade and five with high-grade dysplasia. A multivariate analysis showed relations between age at time of surgery (>or=40 years) and duration of disease (>or=10 years) with a risk for development of mucosectomy area dysplasia.

Conclusion: The incidence of dysplasia of the mucosectomy area was 4.4%, and preoperative risk factors were shown to be duration of disease and age at time of surgery.

Citing Articles

Incidence and Risk Factors of Cancer in the Anal Transitional Zone and Ileal Pouch following Surgery for Ulcerative Colitis and Familial Adenomatous Polyposis.

Le Cosquer G, Buscail E, Gilletta C, Deraison C, Duffas J, Bournet B Cancers (Basel). 2022; 14(3).

PMID: 35158797 PMC: 8833833. DOI: 10.3390/cancers14030530.

Incidence of neoplasias and effectiveness of postoperative surveillance endoscopy for patients with ulcerative colitis: comparison of ileorectal anastomosis and ileal pouch-anal anastomosis.

Ishii H, Hata K, Kishikawa J, Anzai H, Otani K, Yasuda K World J Surg Oncol. 2016; 14:75.

PMID: 26960982 PMC: 4784460. DOI: 10.1186/s12957-016-0833-5.

Large bowel mucosal neoplasia in the original specimen may increase the risk of ileal pouch neoplasia in patients following restorative proctocolectomy for ulcerative colitis.

Bobkiewicz A, Krokowicz L, Paszkowski J, Studniarek A, Szmyt K, Majewski J Int J Colorectal Dis. 2015; 30(9):1261-6.

PMID: 26022647 PMC: 4553144. DOI: 10.1007/s00384-015-2271-1.

Clinical outcomes after restorative proctocolectomy with ileal pouch anal anastomosis using ultrasonically activated scalpel for ulcerative colitis.

Ikeuchi H, Uchino M, Matsuoka H, Bando T, Takesue Y, Tomita N Int Surg. 2012; 97(3):210-8.

PMID: 23113848 PMC: 3723225. DOI: 10.9738/CC60.1.

Surgery for ulcerative colitis in 1,000 patients.

Ikeuchi H, Uchino M, Matsuoka H, Bando T, Matsumoto T, Tomita N Int J Colorectal Dis. 2010; 25(8):959-65.

PMID: 20217422 DOI: 10.1007/s00384-010-0915-8.

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