Crimean-Congo Hemorrhagic Fever Virus Genomics and Global Diversity

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2006 Aug 17

PMID 16912331

Citations 124

Authors

Varough M Deyde

Marina L Khristova

Pierre E Rollin

Thomas G Ksiazek

Stuart T Nichol

Affiliations

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Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high case fatality that occurs in Africa, Europe, the Middle East, and Asia. The complete genomes of 13 geographically and temporally diverse virus strains were determined, and CCHF viruses were found to be highly variable with 20 and 8%, 31 and 27%, and 22 and 10% nucleotide and deduced amino acid differences detected among virus S (nucleocapsid), M (glycoprotein), and L (polymerase) genome segments, respectively. Distinct geographic lineages exist, but with multiple exceptions indicative of long-distance virus movement. Discrepancies among the virus S, M, and L phylogenetic tree topologies document multiple RNA segment reassortment events. An analysis of individual segment datasets suggests genetic recombination also occurs. For an arthropod-borne virus, the genomic plasticity of CCHF virus is surprisingly high.

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