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Serum Insulin-like Growth Factor-I (IGF-I) and Growth in Children Born After Assisted Reproduction

Overview
Specialty Endocrinology
Date 2006 Aug 17
PMID 16912121
Citations 13
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Abstract

Context: Concern has been raised about the safety of assisted reproduction techniques for the offspring.

Objectives: The objective of the study was to investigate postnatal growth and growth factors in children born after intra-cytoplasmatic sperm injection (ICSI) and in vitro fertilization (IVF).

Design: The study had two cohorts: a population-based longitudinal infant cohort 0-36 months [236 ICSI, 173 IVF, 1530 naturally conceived (NC)], and a cross-sectional child cohort at 5 yr (68 ICSI, 67 IVF, 70 NC).

Intervention: Anthropometrical measurements were made at birth, 3, 18, 36 (infant cohort), and 60 months (child cohort), and blood samples were collected at 3 or 60 months.

Main Outcome Measures: Serum IGF-I, IGFBP-3, height, weight, head and abdominal circumference, body mass index, and fat folds were the main outcome measures.

Results: Anthropometrical measurements showed no significant differences between ICSI and IVF children and controls in either cohort. However, singleton ICSI girls [3.4 (0.6) kg, P = 0.008] had a slightly lower birth weight than IVF [3.5 (0.5) kg] and NC girls [3.5 (0.5) kg]. Birth weights of singleton boys [3.6 (0.5) kg], twin boys [2.6 (0.6) kg], and twin girls [2.4 (0.5) kg] did not differ between types of conception. In the infant cohort in 3-month-old singletons, serum IGF-I was lower in ICSI [78 (26) ng/ml] than NC boys [94 (27) ng/ml, P < 0.001] and IVF [74 (34) ng/ml], compared with NC girls [93 (43) ng/ml, P = 0.011]. ICSI children were also smaller than their target height (sd score) at 3 yr of age [mean -0.91 (1.2)], compared with NC children [-0.61 (0.9), P = 0.033]. In the child cohort, target height attainment (sd score) and growth factors did not differ among the three groups.

Conclusions: The overall growth pattern of ICSI and IVF children in both cohorts was normal. Our findings of subtle differences in target height attainment and serum IGF-I levels between infants born after assisted reproduction techniques and controls may not be clinically significant. However, these observations indicate that further systematic follow-up of growth and puberty in these children is needed.

Citing Articles

Overweight or obesity in children born after assisted reproductive technologies in Denmark: A population-based cohort study.

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Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach.

Huang J, Cai S, Huang Z, Thway Tint M, Yuan W, Aris I Nat Commun. 2021; 12(1):5613.

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Health and fertility of ICSI-conceived young men: study protocol.

Catford S, Lewis S, Halliday J, Kennedy J, OBryan M, McBain J Hum Reprod Open. 2020; 2020(4):hoaa042.

PMID: 33033755 PMC: 7532549. DOI: 10.1093/hropen/hoaa042.


Metabolic Syndrome and Its Components in Young Adults Conceived by ICSI.

Belva F, Bonduelle M, Provyn S, Painter R, Tournaye H, Roelants M Int J Endocrinol. 2018; 2018:8170518.

PMID: 29853885 PMC: 5960531. DOI: 10.1155/2018/8170518.


A practical blueprint to systematically study life-long health consequences of novel medically assisted reproductive treatments.

Mulder C, Serrano J, Catsburg L, Roseboom T, Repping S, van Pelt A Hum Reprod. 2018; 33(5):784-792.

PMID: 29635479 PMC: 5925779. DOI: 10.1093/humrep/dey070.