Haptoglobin Gene Promoter Polymorphism and Haplotypes Are Unique in Different Populations

Overview

Journal Hum Biol

Specialty Social Sciences

Date 2006 Aug 12

PMID 16900887

Citations 3

Authors

Kwesi Teye

Mikiko Soejima

Isaac K E Quaye

Hao Pang

Makoto Tsuneoka

Yoshiro Koda

Hiroshi Kimura

Affiliations

Soon will be listed here.

Abstract

We investigated the distribution of haptoglobin (HP) alleles and haplotypes among Africans (Ghanaians), Europeans (from South Africa), and Chinese. HP*1F was present only in Africans and Europeans, whereas HP*del was unique to Chinese. Six base substitutions at the promoter region were population specific. Only 3 out of 18 haplotypes were shared among the populations. A probable application of HP in human population genetics appears legitimate.

Citing Articles

Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination.

Waki K, Yamada T, Yoshiyama K, Terazaki Y, Sakamoto S, Sugawara S Oncol Lett. 2017; 13(2):993-999.

PMID: 28356990 PMC: 5351398. DOI: 10.3892/ol.2016.5467.

Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients.

Araki H, Pang X, Komatsu N, Soejima M, Miyata N, Takaki M Cancer Immunol Immunother. 2015; 64(12):1565-73.

PMID: 26428930 PMC: 11028849. DOI: 10.1007/s00262-015-1756-7.

Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection.

Cox S, Doherty C, Atkinson S, Nweneka C, Fulford A, Ghattas H PLoS One. 2007; 2(4):e362.

PMID: 17426810 PMC: 1838521. DOI: 10.1371/journal.pone.0000362.