Effects of Rabeprazole or Famotidine During Cardiac Surgery on Perioperative Gastric and Esophageal PH Readings

Overview

Journal Jpn J Thorac Cardiovasc Surg

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2006 Aug 11

PMID 16898640

Citations 2

Authors

Shigeyoshi Gon

Yoshihito Irie

Morio Takahashi

Affiliations

Soon will be listed here.

Abstract

Objectives: Upper gastrointestinal bleeding, particularly from a stress-induced duodenal ulcer, is an extremely important perioperative complication in cardiovascular surgery.

Methods: In the present study, 33 patients undergoing elective open heart surgery between July 2000 and February 2001 were allocated to either a famotidine (FAM) or rabeprazole (RPZ) group to examine the perioperative gastric and esophageal pH readings, in conjunction with an investigation into the effect of infection with Helicobacter pylori (HP).

Results: Postoperative upper gastrointestinal bleeding did not occur in either group, and the intraoperative and postoperative mean gastric pH readings, as well as the holding time pH>6, suggested sufficient acid suppression by either drug. Gastric acid secretion was less strongly suppressed in HP-negative patients in the FAM group, but was unaffected by HP infection status in the RPZ group.

Conclusion: The FAM group and RPZ group revealed a sufficient effect of gastric acid suppression. It was indicated that FAM had an insufficient effect of gastric acid suppression for HP-negative patients.

Citing Articles

What is the optimum prophylaxis against gastrointestinal haemorrhage for patients undergoing adult cardiac surgery: histamine receptor antagonists, or proton-pump inhibitors?.

Patel A, Som R Interact Cardiovasc Thorac Surg. 2012; 16(3):356-60.

PMID: 23208652 PMC: 3568807. DOI: 10.1093/icvts/ivs483.

Is routine stress ulcer prophylaxis of benefit for patients undergoing cardiac surgery?.

Shin J, Abah U Interact Cardiovasc Thorac Surg. 2012; 14(5):622-8.

PMID: 22345061 PMC: 3735850. DOI: 10.1093/icvts/ivs019.

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