Meningiomas with Conventional MRI Findings Resembling Intraaxial Tumors: Can Perfusion-weighted MRI Be Helpful in Differentiation?

Overview

Journal Neuroradiology

Specialties Neurology
Radiology

Date 2006 Aug 10

PMID 16896907

Citations 28

Authors

Bahattin Hakyemez

Nalan Yildirim

Cuneyt Erdogan

Hasan Kocaeli

Ender Korfali

Mufit Parlak

Affiliations

Soon will be listed here.

Abstract

Introduction: To investigate the contribution of perfusion-weighted MRI to the differentiation of meningiomas with atypical conventional MRI findings from intraaxial tumors.

Methods: We retrospectively analyzed 54 meningiomas, 12 glioblastomas and 13 solitary metastases. We detected 6 meningiomas with atypical features on conventional MRI resembling intraaxial tumors. The regional cerebral blood flow (rCBV) ratios of all tumors were calculated via perfusion-weighted MRI. The signal intensity-time curves were plotted and three different curve patterns were observed. The type 1 curve resembled normal brain parenchyma or the postenhancement part was minimally below the baseline, the type 2 curve was similar to the type 1 curve but with the postenhancement part above the baseline, and the type 3 curve had the postenhancement part below the baseline accompanied by widening of the curve. Student's t-test was used for statistical analysis.

Results: On CBV images meningiomas were hypervascular and the mean rCBV ratio was 10.58+/-2.00. For glioblastomas and metastatic lesions, the rCBV ratios were 5.02+/-1.40 and 4.68+/-1.54, respectively. There was a statistically significant difference in rCBV ratios between meningiomas and glioblastomas and metastases (P<0.001). Only one of the meningiomas displayed a type 2 curve while five showed a type 3 curve. Glioblastomas and metastases displayed either a type 1 or a type 2 curve. None of the meningiomas showed a type 1 curve and none of the glioblastomas or metastases showed a type 3 curve.

Conclusion: Differentiating meningiomas with atypical conventional MRI findings from malignant intraaxial tumors can be difficult. Calculation of rCBV ratios and construction of signal intensity-time curves may contribute to the differentiation of meningiomas from intraaxial tumors.

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