Tumor of the Liver (hepatocellular and High Grade Neuroendocrine Carcinoma): a Case Report and Review of the Literature

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2006 Aug 10

PMID 16896889

Citations 26

Authors

Monica T Garcia

Pablo A Bejarano

Maria Yssa

Efren Buitrago

Alan Livingstone

Affiliations

Soon will be listed here.

Abstract

We describe a rare hepatic collision tumor composed of a hepatocellular carcinoma and a high-grade neuroendocrine carcinoma. The patient, a 50-year-old man, underwent a partial hepatectomy because of a 5.0-cm mass. The tumor had two distinctive patterns. The majority of the tumor was a high-grade neuroendocrine carcinoma with features of a small cell carcinoma that was positive for chromogranin, synaptophysin, and cytokeratin 19 and negative for hepatocellular antigen and alpha-fetoprotein (AFP). The second component was a moderately differentiated hepatocellular carcinoma that was positive for hepatocellular antigen and AFP and negative for neuroendocrine markers. The two tumors were separated by fibrous bands. In areas where they collided, there was no transition or intermingling of cells between the two components, thus, it is different from the combined type of tumors. After removal of the tumor, the patient had intrahepatic and mesenteric recurrences within a follow-up period of 16 months.

Citing Articles

Mixed Neuroendocrine Non-Neuroendocrine Tumor (MINEN) of the Liver: Report of Two Cases and Review of the Literature.

Mubeen B, Eapen M, Sudhindran S, Haridas N Turk Patoloji Derg. 2024; 41(1):21-29.

PMID: 39268996 PMC: 11831964. DOI: 10.5146/tjpath.2024.13492.

Case report: mixed large-cell neuroendocrine and hepatocellular carcinoma of the liver.

Gao X, Wang H, Niu Z, Liu M, Kong X, Sun H Front Oncol. 2024; 13:1309798.

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Hepatocellular carcinoma‑cavernous hemangioma collision tumor: A case report.

Wu S, Zhang X, Bao J, Sun N, Guo W, Wang B Oncol Lett. 2024; 27(2):74.

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Primary Hepatic Neuroendocrine Carcinoma with Metastasis to the Mesentery: A Case Report.

Fernandez-Ferreira R, Romero-Lopez U, Robles-Avina J, Rivas-Mendoza U, Gonzalez-Camacho C, Valero-Gomez A Case Rep Oncol. 2023; 16(1):681-697.

PMID: 37933308 PMC: 10625823. DOI: 10.1159/000533199.

Combined Hepatocellular Neuroendocrine Carcinoma: A Rare Tumor.

Ahmed Z, Divatia M, Crumley S, Victor D, Kodali S ACG Case Rep J. 2023; 10(7):e00931.

PMID: 37434660 PMC: 10332823. DOI: 10.14309/crj.0000000000000931.

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