Cognitive Correlates of HVOT Performance Differ Between Individuals with Mild Cognitive Impairment and Normal Controls

Overview

Journal Arch Clin Neuropsychol

Publisher Oxford University Press

Specialties Neurology
Psychology

Date 2006 Aug 9

PMID 16893623

Citations 19

Authors

Angela L Jefferson

Sarah Wong

Elizabeth Bolen

Al Ozonoff

Robert C Green

Robert A Stern

Affiliations

Soon will be listed here.

Abstract

Objective: To clinically characterize performance on the Hooper Visual Organization Test (HVOT) among participants with mild cognitive impairment (MCI) and to identify naming and executive functioning correlates associated with HVOT performance among MCI participants and normal controls (NC).

Background: The HVOT is a common neuropsychological instrument that measures visuospatial skills and agnosia. It has, however, been criticized for its multifactorial nature, as several studies have reported executive or language correlates of HVOT performance. To our knowledge, simultaneous comparison of executive functioning and language demands of the HVOT has never been performed among an older cohort.

Methods: The HVOT, two tests of executive functioning [Trail Making Test, Part B (TMT-B), Controlled Oral Word Association (COWA)] and two tests of naming [abbreviated Boston Naming Test (BNT), Animal Naming] were administered to 222 NC, 166 MCI, and 68 Alzheimer's disease (AD) individuals.

Results: HVOT scores were significantly different between all three groups in the expected direction (AD<MCI<NC). Linear regression among NC participants revealed that COWA, age, and BNT were significantly associated with HVOT scores, accounting for 12%, 6%, and 4% of HVOT variance, respectively. Among MCI participants, the BNT accounted for 43% of HVOT variance. Neither TMT-B nor Animal Naming was a significant predictor for either group.

Conclusion: Among NC participants, rapid word generation (i.e., COWA), a measure of executive functioning, is the most salient predictor of HVOT performance. In contrast, lexical retrieval (i.e., BNT) is the most salient language or executive functioning predictor of HVOT performance among MCI participants. These findings extend previous claims that the HVOT is multifactorial by suggesting that reduced HVOT performance in MCI patients may be related to mild lexical retrieval impairments.

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References

Moritz C, Johnson S, McMillan K, Haughton V, Meyerand M . Functional MRI neuroanatomic correlates of the Hooper Visual Organization Test. J Int Neuropsychol Soc. 2005; 10(7):939-47. DOI: 10.1017/s1355617704107042. View

Pihlajamaki M, Tanila H, Hanninen T, Kononen M, Laakso M, Partanen K . Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study. Ann Neurol. 2000; 47(4):470-6. View

Morris J . The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993; 43(11):2412-4. DOI: 10.1212/wnl.43.11.2412-a. View

Petersen R, Smith G, Waring S, Ivnik R, Tangalos E, Kokmen E . Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999; 56(3):303-8. DOI: 10.1001/archneur.56.3.303. View

Abrahams S, Goldstein L, Simmons A, Brammer M, Williams S, Giampietro V . Functional magnetic resonance imaging of verbal fluency and confrontation naming using compressed image acquisition to permit overt responses. Hum Brain Mapp. 2003; 20(1):29-40. PMC: 6872028. DOI: 10.1002/hbm.10126. View

Nadler J, Grace J, White D, Butters M, Malloy P . Laterality differences in quantitative and qualitative Hooper performance. Arch Clin Neuropsychol. 1996; 11(3):223-9. View

Lopez M, Lazar M, Oh S . Psychometric properties of the Hooper Visual Organization Test. Assessment. 2003; 10(1):66-70. DOI: 10.1177/1073191102250183. View

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

Greve K, LINDBERG R, Bianchini K, Adams D . Construct validity and predictive value of the Hooper Visual Organization Test in stroke rehabilitation. Appl Neuropsychol. 2001; 7(4):215-22. DOI: 10.1207/S15324826AN0704_3. View

10.

Fisher N, Tierney M, SNOW W, Szalai J . Odd/Even short forms of the Boston Naming Test: preliminary geriatric norms. Clin Neuropsychol. 2000; 13(3):359-64. DOI: 10.1076/clin.13.3.359.1742. View

11.

Petersen R . Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004; 256(3):183-94. DOI: 10.1111/j.1365-2796.2004.01388.x. View

12.

Lawton M, Brody E . Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969; 9(3):179-86. View

13.

Paul R, Cohen R, Moser D, Ott B, Zawacki T, Gordon N . Performance on the Hooper Visual Organizational Test in patients diagnosed with subcortical vascular dementia: relation to naming performance. Neuropsychiatry Neuropsychol Behav Neurol. 2001; 14(2):93-7. View

14.

Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund L . Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004; 256(3):240-6. DOI: 10.1111/j.1365-2796.2004.01380.x. View

15.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34(7):939-44. DOI: 10.1212/wnl.34.7.939. View

16.

Yesavage J, Brink T, Rose T, Lum O, Huang V, Adey M . Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982; 17(1):37-49. DOI: 10.1016/0022-3956(82)90033-4. View