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Postnatal Growth, Neurodevelopment and Altered Adiposity After Preterm Birth--from a Clinical Nutrition Perspective

Overview
Journal Acta Paediatr
Specialty Pediatrics
Date 2006 Aug 3
PMID 16882561
Citations 29
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Abstract

Unlabelled: Evidence reveals a dilemma that under-nutrition and growth retardation during brain growth are associated with neurodevelopmental deficits, and nutritional supplement resulting in catch-up growth and relative visceral adiposity leads to metabolic/cardiovascular morbidities. Hyperinsulinaemia secondary to insulin resistance appears to play a central role in the development of visceral adiposity through its action on adipocyte beta3-adrenoceptor.

Conclusion: Optimal nutritional management to minimize hyperinsulinaemia and insulin resistance may potentially improve neurodevelopment and facilitate catch-up growth with normal body composition.

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