The Role of Leptin in Innate and Adaptive Immune Responses

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2006 Aug 2

PMID 16879738

Citations 48

Authors

Eiva Bernotiene

Gaby Palmer

Cem Gabay

Affiliations

Soon will be listed here.

Abstract

Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans.

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References

Chatzantoni K, Papathanassopoulos P, Gourzoulidou E, Mouzaki A . Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS.... J Autoimmun. 2004; 23(2):169-77. DOI: 10.1016/j.jaut.2004.05.007. View

Nishiya K, Nishiyama M, Chang A, Shinto A, Hashimoto K . [Serum leptin levels in patients with rheumatoid arthritis are correlated with body mass index]. Rinsho Byori. 2002; 50(5):524-7. View

Chow V, Phoon M . Measurement of serum leptin concentrations in university undergraduates by competitive ELISA reveals correlations with body mass index and sex. Adv Physiol Educ. 2003; 27(1-4):70-7. DOI: 10.1152/advan.00001.2003. View

Jaworek J, Bonior J, Pierzchalski P, Tomaszewska R, Stachura J, Sendur R . Leptin protects the pancreas from damage induced by caerulein overstimulation by modulating cytokine production. Pancreatology. 2002; 2(2):89-99. DOI: 10.1159/000055897. View

Batocchi A, Rotondi M, Caggiula M, Frisullo G, Odoardi F, Nociti V . Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta. J Neuroimmunol. 2003; 139(1-2):150-4. DOI: 10.1016/s0165-5728(03)00154-1. View

Gainsford T, Willson T, Metcalf D, Handman E, McFarlane C, Ng A . Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci U S A. 1996; 93(25):14564-8. PMC: 26173. DOI: 10.1073/pnas.93.25.14564. View

Fraser D, Thoen J, Bondhus S, Haugen M, Reseland J, Djoseland O . Reduction in serum leptin and IGF-1 but preserved T-lymphocyte numbers and activation after a ketogenic diet in rheumatoid arthritis patients. Clin Exp Rheumatol. 2000; 18(2):209-14. View

Shamsuzzaman A, Winnicki M, Wolk R, Svatikova A, Phillips B, Davison D . Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation. 2004; 109(18):2181-5. DOI: 10.1161/01.CIR.0000127960.28627.75. View

Evereklioglu C, Inaloz H, Kirtak N, Doganay S, Bulbul M, Ozerol E . Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity. Br J Dermatol. 2002; 147(2):331-6. DOI: 10.1046/j.1365-2133.2002.04703.x. View

10.

de Hooge A, van De Loo F, Arntz O, van den Berg W . Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis. Am J Pathol. 2000; 157(6):2081-91. PMC: 1885768. DOI: 10.1016/S0002-9440(10)64846-8. View

11.

Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau J, Bortoluzzi M . The stomach is a source of leptin. Nature. 1998; 394(6695):790-3. DOI: 10.1038/29547. View

12.

Ge H, Huang L, Pourbahrami T, Li C . Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem. 2002; 277(48):45898-903. DOI: 10.1074/jbc.M205825200. View

13.

Yang S, Lin H, Schwenk R, Krzych U, Diehl A . Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. Hepatology. 2000; 31(3):633-40. DOI: 10.1002/hep.510310313. View

14.

Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L . A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 1998; 393(6686):684-8. DOI: 10.1038/31474. View

15.

Garcia-Gonzalez A, Gonzalez-Lopez L, Cardona-Munoz E, Salazar-Paramo M, Gonzalez-Ortiz M, Martinez-Abundis E . Serum leptin levels in women with systemic lupus erythematosus. Rheumatol Int. 2002; 22(4):138-41. DOI: 10.1007/s00296-002-0216-9. View

16.

Ottonello L, Gnerre P, Bertolotto M, Mancini M, Dapino P, Russo R . Leptin as a uremic toxin interferes with neutrophil chemotaxis. J Am Soc Nephrol. 2004; 15(9):2366-72. DOI: 10.1097/01.ASN.0000139321.98029.40. View

17.

Trayhurn P, Wood I . Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans. 2005; 33(Pt 5):1078-81. DOI: 10.1042/BST0331078. View

18.

Palmer G, Gabay C . A role for leptin in rheumatic diseases?. Ann Rheum Dis. 2003; 62(10):913-5. PMC: 1754337. DOI: 10.1136/ard.62.10.913. View

19.

Trayhurn P . Thermoregulation in the diabetic-obese (db/db) mouse. The role of non-shivering thermogenesis in energy balance. Pflugers Arch. 1979; 380(3):227-32. DOI: 10.1007/BF00582901. View

20.

Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D . Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol. 2002; 168(2):875-82. DOI: 10.4049/jimmunol.168.2.875. View