Pedimune in Recurrent Respiratory Infection and Diarrhoea--the Indian Experience--the Pride Study

Overview

Journal Indian J Pediatr

Specialty Pediatrics

Date 2006 Aug 1

PMID 16877852

Citations 13

Authors

Kamlesh Patel

Rajiv Rana

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the efficacy and tolerability of bovine colostrum in preventing recurrent episodes of upper respiratory tract infections and diarrhoea in children

Methods: 605 children (1-8 yrs) having recurrent episodes of upper respiratory tract infections or diarrhea received Bovine Colostrum (Pedimune) for 12 weeks. Total no of episodes of recurrent infections, hospitalization rate, overall well being and adverse events were assessed at every 4 weeks.

Results: Episodes of URTI and diarrhoea reduced significantly by 91.19 % and 86.60% at the end of therapy respectively. High to average improvement in overall well-being in 96 % of the patients were found by pediatrician while overall well-being stated by the patient/care taker was very good to good in 90.56 % of the patients.

Conclusion: Bovine colostrum was highly effective in the prophylactic treatment of recurrent URTIs and diarrhea in reducing not only the episodes but also the hospitalization due to them.

Citing Articles

Bovine Colostrum in Pediatric Nutrition and Health.

Canbolat A, Lombardo M, Mondragon A, Lopez J, Bechelany M, Karav S Nutrients. 2025; 16(24.

PMID: 39770926 PMC: 11677144. DOI: 10.3390/nu16244305.

Bovine colostrum and its potential contributions for treatment and prevention of COVID-19.

Duman H, Karav S Front Immunol. 2023; 14:1214514.

PMID: 37908368 PMC: 10613682. DOI: 10.3389/fimmu.2023.1214514.

Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children.

Halasa M, Skonieczna-Zydecka K, Machalinski B, Buhner L, Baskiewicz-Halasa M Nutrients. 2023; 15(16).

PMID: 37630816 PMC: 10459079. DOI: 10.3390/nu15163626.

Colostrum and Lactoferrin Protect against Side Effects of Therapy with Antibiotics, Anti-inflammatory Drugs and Steroids, and Psychophysical Stress: A Comprehensive Review.

Artym J, Zimecki M Biomedicines. 2023; 11(4).

PMID: 37189633 PMC: 10136316. DOI: 10.3390/biomedicines11041015.

Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract Infections in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial.

Baskiewicz-Halasa M, Stachowska E, Grochans E, Maciejewska-Markiewicz D, Buhner L, Skonieczna-Zydecka K Nutrients. 2023; 15(8).

PMID: 37111143 PMC: 10146600. DOI: 10.3390/nu15081925.

References

Bogstedt A, Johansen K, Hatta H, Kim M, Casswall T, Svensson L . Passive immunity against diarrhoea. Acta Paediatr. 1996; 85(2):125-8. DOI: 10.1111/j.1651-2227.1996.tb13975.x. View

Brinkworth G, Buckley J . Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr. 2003; 42(4):228-32. DOI: 10.1007/s00394-003-0410-x. View

Korhonen H, Syvaoja E, Sivela S, Kopola S, Husu J, Kosunen T . Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobacter pylori. J Appl Bacteriol. 1995; 78(6):655-62. DOI: 10.1111/j.1365-2672.1995.tb03112.x. View

Nakamura T, Kawase H, Kimura K, Watanabe Y, Ohtani M, Arai I . Concentrations of sialyloligosaccharides in bovine colostrum and milk during the prepartum and early lactation. J Dairy Sci. 2003; 86(4):1315-20. DOI: 10.3168/jds.S0022-0302(03)73715-1. View

Mero A, Kahkonen J, Nykanen T, Parviainen T, Jokinen I, Takala T . IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. J Appl Physiol (1985). 2002; 93(2):732-9. DOI: 10.1152/japplphysiol.00002.2002. View

Cunningham-Rundles C, Pudifin D, Armstrong D, GOOD R . Selective IgA deficiency and neoplasia. Vox Sang. 1980; 38(2):61-7. DOI: 10.1111/j.1423-0410.1980.tb02332.x. View

Mitra A, Mahalanabis D, Ashraf H, Unicomb L, EECKELS R, Tzipori S . Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial. Acta Paediatr. 1995; 84(9):996-1001. DOI: 10.1111/j.1651-2227.1995.tb13814.x. View

Carbonare S, Silva M, Palmeira P, Carneiro-Sampaio M . Human colostrum IgA antibodies reacting to enteropathogenic Escherichia coli antigens and their persistence in the faeces of a breastfed infant. J Diarrhoeal Dis Res. 1997; 15(2):53-8. View

Nord J, Ma P, DiJohn D, Tzipori S, Tacket C . Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients. AIDS. 1990; 4(6):581-4. DOI: 10.1097/00002030-199006000-00015. View

10.

Sanchez L, Calvo M, Brock J . Biological role of lactoferrin. Arch Dis Child. 1992; 67(5):657-61. PMC: 1793702. DOI: 10.1136/adc.67.5.657. View

11.

Paramesh H . Practical approach to recurrent respiratory infections. Indian J Pediatr. 1996; 63(2):181-7. DOI: 10.1007/BF02845242. View

12.

Levay P, Viljoen M . Lactoferrin: a general review. Haematologica. 1995; 80(3):252-67. View

13.

de Vries E . Immunological investigations in children with recurrent respiratory infections. Paediatr Respir Rev. 2005; 2(1):32-6. DOI: 10.1053/prrv.2000.0099. View

14.

Antonio J, Sanders M, Van Gammeren D . The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001; 17(3):243-7. DOI: 10.1016/s0899-9007(00)00552-9. View

15.

Sarker S, Casswall T, Mahalanabis D, Alam N, Albert M, Brussow H . Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J. 1999; 17(12):1149-54. DOI: 10.1097/00006454-199812000-00010. View

16.

Reiter B . Review of the progress of dairy science: antimicrobial systems in milk. J Dairy Res. 1978; 45(1):131-47. DOI: 10.1017/s0022029900016290. View

17.

Brussow H, HILPERT H, Walther I, Sidoti J, MIETENS C, Bachmann P . Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis. J Clin Microbiol. 1987; 25(6):982-6. PMC: 269120. DOI: 10.1128/jcm.25.6.982-986.1987. View

18.

Mero A, Miikkulainen H, Riski J, Pakkanen R, Aalto J, Takala T . Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol (1985). 1997; 83(4):1144-51. DOI: 10.1152/jappl.1997.83.4.1144. View

19.

. Persistent diarrhoea in children in developing countries: memorandum from a WHO meeting. Bull World Health Organ. 1988; 66(6):709-17. PMC: 2491148. View

20.

Liblau R, Bach J . Selective IgA deficiency and autoimmunity. Int Arch Allergy Immunol. 1992; 99(1):16-27. DOI: 10.1159/000236330. View