A Role for CD8+ T Lymphocytes in the Pathogenesis of AIDS

Overview

Journal Res Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 1991 Sep 1

PMID 1687487

Citations 4

Affiliations

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Abstract

Experimental and clinical evidence is presented which supports the hypothesis that CD8+ T lymphocytes aimed at suppressing HIV replication in infected CD4+ T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4+ T lymphocyte numbers. Possible models to test this hypothesis are discussed.

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