IL-10 is Essential for Disease Protection Following Intranasal Peptide Administration in the C57BL/6 Model of EAE

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2006 Jul 29

PMID 16872684

Citations 38

Authors

Emma J ONeill

Michael J Day

David C Wraith

Affiliations

Soon will be listed here.

Abstract

We have shown previously that intranasal administration of encephalitogenic peptides in soluble form to H-2u and H-2s mice affords protection from experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that this method of disease protection can be induced in C57BL/6 mice by administration of the soluble peptide 35-55 from myelin oligodendrocyte glycoprotein. This protective effect was demonstrated by the evaluation of both clinical EAE scores and central nervous system histopathology; the latter showing minimal inflammatory infiltrates in treated mice. The employment of an IL-10-/- congenic strain allowed an appraisal of the involvement of IL-10 in this process. The lack of disease protection in these mice clearly demonstrates the non-redundant role of IL-10 in this process.

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