Pattern Recognition Receptors: a Contemporary View on Liver Diseases

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2006 Jul 28

PMID 16871558

Citations 85

Authors

Gyongyi Szabo

Angela Dolganiuc

Pranoti Mandrekar

Affiliations

Soon will be listed here.

Abstract

Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.

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