[Drug Treatment of Anxiety Disorders]
Overview
Affiliations
Current customary medication with anxiolytic potential has different main-points of impact and individual potentials of risk, which influence strategies of therapy in a limiting way. Benzodiazepines--which are very effective in various anxiety-disorders--can therefore only be applied under well controllable conditions within a limited period of time, in order to reduce the risks of dependency. Also administration of low-doses neuroleptica--which within these doses also show a high potential of anxiety-impact beside a high tolerance--must be limited to a period of two or three months to prevent late development of dyskinesias. Main indications for the application of antidepressive drugs are panic-conditions, cases of phobia and depressive anxiety. In the following a therapy-pattern for management of panic-conditions with Clomipramin will be gone into more detailed. Complementary anxiolytic characteristics of Buspiron and beta-blockers with their specific indication-fields will be brought up.
Decreased anxiety in mice lacking the organic cation transporter 3.
Wultsch T, Grimberg G, Schmitt A, Painsipp E, Wetzstein H, Breitenkamp A J Neural Transm (Vienna). 2009; 116(6):689-97.
PMID: 19280114 DOI: 10.1007/s00702-009-0205-1.