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Design of Chiral N-triflyl Phosphoramide As a Strong Chiral Brønsted Acid and Its Application to Asymmetric Diels-Alder Reaction

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Journal J Am Chem Soc
Specialty Chemistry
Date 2006 Jul 27
PMID 16866505
Citations 60
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Abstract

A highly reactive and acidic chiral Brønsted acid catalyst, chiral N-triflyl phosphoramide, was developed. Highly enantioselective Diels-Alder reaction of alpha,beta-unsaturated ketone with silyloxydiene was demonstrated using this chiral Brønsted acid catalyst.

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