Linkage Disequilibrium Mapping in Domestic Dog Breeds Narrows the Progressive Rod-cone Degeneration Interval and Identifies Ancestral Disease-transmitting Chromosome

Overview

Journal Genomics

Specialty Genetics

Date 2006 Jul 25

PMID 16859891

Citations 46

Authors

Orly Goldstein

Barbara Zangerl

Sue Pearce-Kelling

Duska J Sidjanin

James W Kijas

Jeanette Felix

Gregory M Acland

Gustavo D Aguirre

Affiliations

Soon will be listed here.

Abstract

Canine progressive rod-cone degeneration (prcd) is a retinal disease previously mapped to a broad, gene-rich centromeric region of canine chromosome 9. As allelic disorders are present in multiple breeds, we used linkage disequilibrium (LD) to narrow the approximately 6.4-Mb interval candidate region. Multiple dog breeds, each representing genetically isolated populations, were typed for SNPs and other polymorphisms identified from BACs. The candidate region was initially localized to a 1.5-Mb zero recombination interval between growth factor receptor-bound protein 2 (GRB2) and SEC14-like 1 (SEC14L). A fine-scale haplotype of the region was developed, which reduced the LD interval to 106 kb and identified a conserved haplotype of 98 polymorphisms present in all prcd-affected chromosomes from 14 different dog breeds. The findings strongly suggest that a common ancestor transmitted the prcd disease allele to many of the modern dog breeds and demonstrate the power of the LD approach in the canine model.

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