Modulations in the Intestinal Disaccharide Hydrolases and Membrane Dynamics: Effect of Non-steroidal Anti-inflammatory Drugs Aspirin and Nimesulide

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2006 Jul 21

PMID 16855794

Citations 1

Authors

Naveen Kaushal

S N Sanyal

Affiliations

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Abstract

The present study was designed to evaluate the influence of two commonly prescribed non-steroidal anti-inflammatory drugs (NSAIDs), aspirin and nimesulide on the biochemical composition and membrane dynamics of rat intestine. Female Wistar rats were divided into three different groups viz: Group I (Control), Group II (aspirin-treated, 50 mg/kg body weight) and Group III (nimesulide-treated, 10 mg/kg body weight). After 28 days, biochemical estimations in both drug treated groups showed an increase in sucrase, lactase, maltase and alkaline phosphatase as compared to the control. Alterations in the intestinal membrane dynamics by fluidity studies and Fourier Transform Infra Red (FTIR) spectroscopy also showed considerable changes. The alterations in the histoarchitecture of the intestine were also seen, which correlated well with the changes in structure and composition of the intestine. The use of NSAIDs like aspirin and nimesulide may cause the gastrointestinal side effects due to initial changes in the enzyme activities and membrane dynamics.

Citing Articles

Resolution of Cox mediated inflammation by Se supplementation in mouse experimental model of colitis.

Kaur R, Thakur S, Rastogi P, Kaushal N PLoS One. 2018; 13(7):e0201356.

PMID: 30063735 PMC: 6067745. DOI: 10.1371/journal.pone.0201356.

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