Transcriptional Profile of Haemophilus Influenzae: Effects of Iron and Heme

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2006 Jul 21

PMID 16855256

Citations 21

Authors

Paul W Whitby

Timothy M VanWagoner

Thomas W Seale

Daniel J Morton

Terrence L Stull

Affiliations

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Abstract

Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies of H. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing approximately 10% of the genome, with > or =1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

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