Pathogenic Role and Clinical Relevance of Antineutrophil Cytoplasmic Antibodies in Vasculitides

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2006 Jul 15

PMID 16839508

Citations 5

Authors

Ora Shovman

Boris Gilburd

Gisele Zandman-Goddard

Yaniv Sherer

Yehuda Shoenfeld

Affiliations

Soon will be listed here.

Abstract

Within the last year, a growing body of evidence for a distinct role of antineutrophil cytoplasmic antibodies (ANCA) in the pathogenesis of ANCA-associated vasculitides (AAV) has developed. An experimental model of myeloperoxidase (MPO)-ANCA-associated vasculitis provided direct and convincing in vivo evidence that MPO-ANCA are primary pathogenic factors in small-vessel vasculitis by augmenting of leukocyte-vessel wall interaction and leukocyte-mediated vascular injury. Determination of bacterial lipopolysaccharide (LPS) effects on disease severity in a mouse model of anti-MPO-induced glomerulonephritis showed that ANCA and other proinflammatory stimuli of infectious origin acted in synergism in the development of destructive inflammation.

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