First-pass Metabolism of Cyclosporin by the Gut

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1991 Dec 14

PMID 1683920

Citations 94

Authors

J C Kolars

W M Awni

R M Merion

P B Watkins

Affiliations

Soon will be listed here.

Abstract

Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.

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