Tickborne Arbovirus Surveillance in Market Livestock, Nairobi, Kenya

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2006 Jul 14

PMID 16836823

Citations 38

Authors

Rosemary Sang

Clayton Onyango

John Gachoya

Ernest Mabinda

Samson Konongoi

Victor Ofula

Lee Dunster

Fred Okoth

Rodney Coldren

Robert Tesh

Amelia Travassos da Rossa

Stacy Finkbeiner

David Wang

Mary Crabtree

Barry Miller

Affiliations

Soon will be listed here.

Abstract

To identify tickborne viruses circulating in Kenya and the surrounding region, we conducted surveillance at abattoirs in Nairobi, Kenya. Species of ticks collected included Rhipicephalus pulchellus (56%), Amblyomma gemma (14%), R. appendiculatus (8%), A. variegatum (6%), and others. A total of 56 virus isolates were obtained, 26 from A. gemma, 17 from R. pulchellus, 6 from A. variegatum, and 7 from other species. Virus isolates included Dugbe virus (DUGV), an unknown virus related to DUGV, Thogoto, Bhanja, Kadam, Dhori, Barur, and foot-and-mouth disease (FMDV) viruses. This is the first report of Dhori virus isolation in East Africa and the first known isolation of FMDV associated with tick collection. Our results demonstrate the potential for tickborne dissemination of endemic and emergent viruses and the relevance of A. gemma in the maintenance of tickborne viruses in this region.

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References

Thomson G, Doube B, Braak L, Gainaru M, Bengis R . Failure of Haematobia thirouxi potans (Bezzi) to transmit foot-and-mouth disease virus mechanically between viraemic and susceptible cattle. Onderstepoort J Vet Res. 1988; 55(2):121-2. View

Davies G . Foot and mouth disease. Res Vet Sci. 2002; 73(3):195-9. DOI: 10.1016/s0034-5288(02)00105-4. View

Butenko A, Leshchinskaia E, Semashko I, Donets M, MARTIANOVA L . [Dhori virus--a causative agent of human disease. 5 cases of laboratory infection]. Vopr Virusol. 1987; 32(6):724-9. View

Swanepoel R, Struthers J, Shepherd A, MCGILLIVRAY G, Nel M, Jupp P . Crimean-congo hemorrhagic fever in South Africa. Am J Trop Med Hyg. 1983; 32(6):1407-15. DOI: 10.4269/ajtmh.1983.32.1407. View

Burt F, Spencer D, Leman P, Patterson B, Swanepoel R . Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia. Epidemiol Infect. 1996; 116(3):353-61. PMC: 2271429. DOI: 10.1017/s0950268800052687. View

van Vuuren C, Blouin E, Potgieter F, Thomson G . Rhipicephalus zambeziensis unlikely to transmit foot-and-mouth disease virus. Onderstepoort J Vet Res. 1993; 60(1):75-7. View

Swanepoel R, Shepherd A, Leman P, Shepherd S, MCGILLIVRAY G, Erasmus M . Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa. Am J Trop Med Hyg. 1987; 36(1):120-32. DOI: 10.4269/ajtmh.1987.36.120. View

Gailiunas P, COTTRAL G . Survival of foot-and-mouth disease virus in bovine hides. Am J Vet Res. 1967; 28(125):1047-53. View

Wang D, Urisman A, Liu Y, Springer M, Ksiazek T, Erdman D . Viral discovery and sequence recovery using DNA microarrays. PLoS Biol. 2003; 1(2):E2. PMC: 261870. DOI: 10.1371/journal.pbio.0000002. View

10.

Tukei P, Williams M, Mukwaya L, Henderson B, KAFUKO G, McCRAE A . Virus isolations from Ixodid ticks in Uganda. I. Isolation and characterisation of ten strains of a virus not previously described from Eastern Africa. East Afr Med J. 1970; 47(5):265-72. View

11.

Butenko A, Gromashevsky V, Lvov D, Popov V . First isolations of Barur virus (Rhabdoviridae) from ticks (Acari: Ixodidae) in Africa. J Med Entomol. 1981; 18(3):232-4. DOI: 10.1093/jmedent/18.3.232. View

12.

Filipe A, Casals J . Isolation of Dhori virus from Hyalomma marginatum ticks in Portugal. Intervirology. 1979; 11(2):124-7. DOI: 10.1159/000149023. View

13.

Johnson B, Chanas A, Squires E, Shockley P, Simpson D, Parsons J . Arbovirus isolations from ixodid ticks infesting livestock, Kano Plain, Kenya. Trans R Soc Trop Med Hyg. 1980; 74(6):732-7. DOI: 10.1016/0035-9203(80)90188-1. View

14.

Dunster L, Dunster M, Ofula V, Beti D, Burt F, Swanepoel R . First documentation of human Crimean-Congo hemorrhagic fever, Kenya. Emerg Infect Dis. 2002; 8(9):1005-6. PMC: 2732535. DOI: 10.3201/eid0809.010510. View

15.

Wang D, Coscoy L, Zylberberg M, Avila P, Boushey H, Ganem D . Microarray-based detection and genotyping of viral pathogens. Proc Natl Acad Sci U S A. 2002; 99(24):15687-92. PMC: 137777. DOI: 10.1073/pnas.242579699. View

16.

Calisher C, KARABATSOS N, Filipe A . Antigenic uniformity of topotype strains of Thogoto virus from Africa, Europe, and Asia. Am J Trop Med Hyg. 1987; 37(3):670-3. DOI: 10.4269/ajtmh.1987.37.670. View

17.

Fisher-Hoch S, Khan J, Rehman S, Mirza S, Khurshid M, McCormick J . Crimean Congo-haemorrhagic fever treated with oral ribavirin. Lancet. 1995; 346(8973):472-5. DOI: 10.1016/s0140-6736(95)91323-8. View

18.

Wood O, Lee V, Ash J, Casals J . Crimean-congo hemorrhagic fever, Thogoto, dugbe, and Jos viruses isolated from ixodid ticks in Ethiopia. Am J Trop Med Hyg. 1978; 27(3):600-4. DOI: 10.4269/ajtmh.1978.27.600. View

19.

Casals J, Tignor G . The Nairovirus genus: serological relationships. Intervirology. 1980; 14(3-4):144-7. DOI: 10.1159/000149175. View

20.

Lvov D, Dzharkenov A, Aristova V, Kovtunov A, Gromashevskii V, Vyshemirskii O . [The isolation of Dhori viruses (Orthomyxoviridae, Thogotovirus) and Crimean-Congo hemorrhagic fever virus (Bunyaviridae, Nairovirus) from the hare (Lepus europaeus) and its ticks Hyalomma marginatum in the middle zone of the Volga delta, Astrakhan...]. Vopr Virusol. 2002; 47(4):32-6. View