Synthesis and Evaluation of Biological Properties of Benzylideneacetophenone Derivatives

Overview

Journal Arch Pharm Res

Specialty Pharmacology

Date 2006 Jul 13

PMID 16833013

Citations 8

Authors

Seikwan Oh

Soyong Jang

Donghyun Kim

Inn-Oc Han

Jae-Chul Jung

Affiliations

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Abstract

A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.

Citing Articles

The Anti-Inflammatory Activities of Benzylideneacetophenone Derivatives in LPS Stimulated BV2 Microglia Cells and Mice.

Kim M, Kang S, Oh S Biomol Ther (Seoul). 2024; 33(1):106-116.

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Synthesis of alnustone-like diarylpentanoids via a 4 + 1 strategy and assessment of their potential anticancer activity.

Celebioglu N, Tozlu O, Turkez H, Secen H Turk J Chem. 2024; 47(5):1249-1259.

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JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation.

Lee G, Ahn H, Yun J, Park J, Lee E, Oh S Sci Rep. 2022; 12(1):22484.

PMID: 36577816 PMC: 9797494. DOI: 10.1038/s41598-022-27129-3.

Alleviation of Atopic Dermatitis Lesions by a Benzylideneacetophenone Derivative via the MAPK Signaling Pathway.

Sur B, Kang S, Kim M, Oh S Inflammation. 2019; 42(3):1093-1102.

PMID: 30729380 DOI: 10.1007/s10753-019-00971-w.

Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1β-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative.

Sur B, Kang S, Kim M, Oh S Inflammation. 2018; 42(3):928-936.

PMID: 30565030 PMC: 6527524. DOI: 10.1007/s10753-018-0947-8.