Aortic Arch Atheroma and the Risk of Stroke

Overview

Journal Curr Atheroscler Rep

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2006 Jul 11

PMID 16822402

Citations 3

Authors

Pierre Amarenco

Joachim Rother

Patrik Michel

Steven M Davis

Geoffrey A Donnan

Affiliations

Soon will be listed here.

Abstract

Brain infarction of unknown cause, known as cryptogenic stroke, represents 30% to 40% of all ischemic strokes, or approximately 400,000 cases each year in western Europe. In this category of patients new potential causes, such as aortic arch atheroma in the elderly, have been investigated in the past two decades.

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References

. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996; 348(9038):1329-39. DOI: 10.1016/s0140-6736(96)09457-3. View

Harker L, Marzec U, Kelly A, Chronos N, Sundell I, Hanson S . Clopidogrel inhibition of stent, graft, and vascular thrombogenesis with antithrombotic enhancement by aspirin in nonhuman primates. Circulation. 1998; 98(22):2461-9. DOI: 10.1161/01.cir.98.22.2461. View

Cohen A, Tzourio C, Bertrand B, Chauvel C, Bousser M, Amarenco P . Aortic plaque morphology and vascular events: a follow-up study in patients with ischemic stroke. FAPS Investigators. French Study of Aortic Plaques in Stroke. Circulation. 1997; 96(11):3838-41. DOI: 10.1161/01.cir.96.11.3838. View

Tunick P, Perez J, Kronzon I . Protruding atheromas in the thoracic aorta and systemic embolization. Ann Intern Med. 1991; 115(6):423-7. DOI: 10.7326/0003-4819-115-6-423. View

Davila-Roman V, Murphy S, Nickerson N, Kouchoukos N, Schechtman K, Barzilai B . Atherosclerosis of the ascending aorta is an independent predictor of long-term neurologic events and mortality. J Am Coll Cardiol. 1999; 33(5):1308-16. DOI: 10.1016/s0735-1097(99)00034-0. View

. A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin. The Stroke Prevention in Reversible Ischemia Trial (SPIRIT) Study Group. Ann Neurol. 1997; 42(6):857-65. DOI: 10.1002/ana.410420606. View

Stone D, Hawke M, LaMonte M, Kittner S, Acosta J, Corretti M . Ulcerated atherosclerotic plaques in the thoracic aorta are associated with cryptogenic stroke: a multiplane transesophageal echocardiographic study. Am Heart J. 1995; 130(1):105-8. DOI: 10.1016/0002-8703(95)90243-0. View

Yusuf S, Zhao F, Mehta S, Chrolavicius S, Tognoni G, Fox K . Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001; 345(7):494-502. DOI: 10.1056/NEJMoa010746. View

Diener H, Bogousslavsky J, Brass L, Cimminiello C, Csiba L, Kaste M . Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004; 364(9431):331-7. DOI: 10.1016/S0140-6736(04)16721-4. View

10.

Steinhubl S, Berger P, Mann 3rd J, Fry E, DeLago A, Wilmer C . Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002; 288(19):2411-20. DOI: 10.1001/jama.288.19.2411. View

11.

Di Tullio M, Sacco R, Gersony D, Nayak H, Weslow R, Kargman D . Aortic atheromas and acute ischemic stroke: a transesophageal echocardiographic study in an ethnically mixed population. Neurology. 1996; 46(6):1560-6. DOI: 10.1212/wnl.46.6.1560. View

12.

Mitusch R, Doherty C, WUCHERPFENNIG H, Memmesheimer C, Tepe C, Stierle U . Vascular events during follow-up in patients with aortic arch atherosclerosis. Stroke. 1997; 28(1):36-9. DOI: 10.1161/01.str.28.1.36. View

13.

Davila-Roman V, Barzilai B, Wareing T, Murphy S, Schechtman K, Kouchoukos N . Atherosclerosis of the ascending aorta. Prevalence and role as an independent predictor of cerebrovascular events in cardiac patients. Stroke. 1994; 25(10):2010-6. DOI: 10.1161/01.str.25.10.2010. View

14.

Petty G, Brown Jr R, Whisnant J, Sicks J, OFallon W, Wiebers D . Frequency of major complications of aspirin, warfarin, and intravenous heparin for secondary stroke prevention. A population-based study. Ann Intern Med. 1999; 130(1):14-22. DOI: 10.7326/0003-4819-130-1-199901050-00004. View

15.

Tunick P, Rosenzweig B, Katz E, Freedberg R, Perez J, Kronzon I . High risk for vascular events in patients with protruding aortic atheromas: a prospective study. J Am Coll Cardiol. 1994; 23(5):1085-90. DOI: 10.1016/0735-1097(94)90595-9. View

16.

Mohr J, Thompson J, Lazar R, Levin B, Sacco R, Furie K . A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med. 2002; 345(20):1444-51. DOI: 10.1056/NEJMoa011258. View

17.

Amarenco P, Donnan G . Should the MATCH results be extrapolated to all stroke patients and affect ongoing trials evaluating clopidogrel plus aspirin?. Stroke. 2004; 35(11):2606-8. DOI: 10.1161/01.STR.0000145053.27085.66. View

18.

Amarenco P, Cohen A, Hommel M, Moulin T, Leys D, Bousser M . Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke. N Engl J Med. 1996; 334(19):1216-21. DOI: 10.1056/NEJM199605093341902. View

19.

Amarenco P, Cohen A, Tzourio C, Bertrand B, Hommel M, Besson G . Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Engl J Med. 1994; 331(22):1474-9. DOI: 10.1056/NEJM199412013312202. View

20.

Tunick P, Nayar A, Goodkin G, Mirchandani S, Francescone S, Rosenzweig B . Effect of treatment on the incidence of stroke and other emboli in 519 patients with severe thoracic aortic plaque. Am J Cardiol. 2002; 90(12):1320-5. DOI: 10.1016/s0002-9149(02)02870-9. View