Survivin Expression in Pre-invasive Lesions and Non-small Cell Lung Carcinoma

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2006 Jul 1

PMID 16810543

Citations 14

Authors

Nalan Akyurek

Leyla Memis

Ozgur Ekinci

Nurdan Kokturk

Can Ozturk

Affiliations

Soon will be listed here.

Abstract

Survivin is an inhibitor of apoptosis protein, which is overexpressed in many carcinomas, including lung carcinoma. The aim of this immunohistochemical study was to investigate the role of survivin in the early steps of lung carcinogenesis and non-small cell lung carcinomas (NSCLC), and its relationship with expression of p53 protein, a tumor suppressor gene involved in cell cycle control. In the normal bronchial epithelium, low-grade atypical adenomatous hyperplasia (AAH) and non-neoplastic lung parenchyma adjacent to tumor, survivin was found completely negative. Expression of survivin was detected in the areas of squamous metaplasia and dysplasia as well as high-grade AAH lesions adjacent to tumor. Survivin was expressed in 50 (64%) and p53 in 41 (53%) NSCLC. Survivin expression was significantly correlated with lymph node metastasis (p=0.02). There was no correlation between survivin and p53 expression. The patients with expression of survivin had significantly worse prognosis (Log-rank test, p=0.003). Multivariate Cox regression analysis showed TNM stage (p<0.001) and survivin expression (p=0.003) as independent prognostic indicators. In conclusion, survivin expression might be an early step in lung carcinogenesis. Survivin expression might also be used as a prognostic indicator predicting the worse outcome in NSCLC, and might be a novel target for the treatment of patients with preinvasive lesions of lung and NSCLC.

Citing Articles

Bioinformatics analysis of BIRC5 in human cancers.

Ye H, Ma B, Meng G, Tao S, Wang Y, Chen Z Ann Transl Med. 2022; 10(16):888.

PMID: 36111008 PMC: 9469138. DOI: 10.21037/atm-22-3496.

Clinicopathological and Prognostic Significance of Inhibitor of Apoptosis Protein (IAP) Family Members in Lung Cancer: A Meta-Analysis.

Fung S, Knoefel W, Krieg A Cancers (Basel). 2021; 13(16).

PMID: 34439255 PMC: 8392569. DOI: 10.3390/cancers13164098.

Survivin expression modulates the sensitivity of A549 lung cancer cells resistance to vincristine.

Zhou C, Zhu Y, Lu B, Zhao W, Zhao X Oncol Lett. 2018; 16(4):5466-5472.

PMID: 30250619 PMC: 6144891. DOI: 10.3892/ol.2018.9277.

Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis.

Duan L, Hu X, Jin Y, Liu R, You Q BMC Cancer. 2016; 16:276.

PMID: 27090386 PMC: 4836165. DOI: 10.1186/s12885-016-2304-3.

Survivin expression is an independent poor prognostic marker in lung adenocarcinoma but not in squamous cell carcinoma.

Sun P, Jin Y, Kim H, Seo A, Jheon S, Lee C Virchows Arch. 2013; 463(3):427-36.

PMID: 23907568 DOI: 10.1007/s00428-013-1462-9.

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