Evidence for the Existence of Postsynaptic Beta-1 and Beta-2 Adrenoceptors in Isolated Simian Facial Veins

Overview

Journal Heart Vessels

Specialty Cardiology & Vascular Diseases

Date 1991 Jan 1

PMID 1680847

Citations 1

Authors

S Chiba

M Tsukada

Affiliations

Soon will be listed here.

Abstract

With the use of a steel cannula inserting method, the actions of the beta-adrenoceptor agonists, noradrenaline (NA, a mixed agonist), isoprenaline (a mixed agonist), dobutamine (a selective beta-1 agonist), salbutamol, and procaterol (selective beta-2 agonists), were investigated on isolated and perfused simian facial veins. Each beta-agonist usually induced a vasodilation in a dose-related manner in non-preconstricted vessel preparations. The rank order of potency was isoprenaline much greater than NA greater than dobutamine greater than salbutamol greater than procaterol. NA- and isoprenaline-induced vasodilations were inhibited by either metoprolol (a selective beta-1 adrenoceptor antagonist) or ICI 118,551 (a selective beta-2 antagonist). After beta-1 blockade, NA produced a vasoconstriction which was readily blocked by bunazosin (an alpha-1 antagonist). Dobutamine-induced vasodilations were strongly suppressed by metoprolol and slightly blocked by ICI 118,551. Salbutamol-induced vasodilations were blocked by metoprolol, while ICI 118,551 more markedly inhibited these dilations. From these results, it was concluded that there are abundant beta-adrenoceptors and predominantly beta-1 adrenoceptors in isolated simian facial veins.

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PMID: 8924752 DOI: 10.1007/BF02291402.

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