Intrauterine Breast Development and the Mammary Myoepithelial Lineage

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2006 Jun 30

PMID 16807800

Citations 10

Authors

Francine Jolicoeur

Affiliations

Soon will be listed here.

Abstract

As their name implies, the myoepithelial cells found at the epithelial-mesenchymal interface of the human mammary gland disclose features suggestive of a dual epithelial-like and muscle-like differentiation, i.e. they co-express various keratins and vimentin intermediate filaments, as well as smooth muscle-related antigens. This article provides an overview of the literature on intrauterine breast development with special emphasis on the myoepithelial component of the fetal human mammary gland epithelium. It discusses original and recently published immunohistochemical data on myoepithelial precursors and reasserts the relevance of developmental, morphological fetal tissue-based studies to the understanding and the clinical management of adult diseases.

Citing Articles

Effects of a blend extract of , , and on milk production in lactating rats.

Intan P, Alegantina S, Isnawati A, Yunarto N, Ekawasti F, Rinendyaputri R Open Vet J. 2025; 14(12):3630-3639.

PMID: 39927372 PMC: 11799640. DOI: 10.5455/OVJ.2024.v14.i12.44.

Re-evaluation of the myoepithelial cells roles in the breast cancer progression.

Shams A Cancer Cell Int. 2022; 22(1):403.

PMID: 36510219 PMC: 9746125. DOI: 10.1186/s12935-022-02829-y.

The Mammary Gland: Basic Structure and Molecular Signaling during Development.

Biswas S, Banerjee S, Baker G, Kuo C, Chowdhury I Int J Mol Sci. 2022; 23(7).

PMID: 35409243 PMC: 8998991. DOI: 10.3390/ijms23073883.

Context-Dependent Function of Myoepithelial Cells in Breast Morphogenesis and Neoplasia.

Ingthorsson S, Hilmarsdottir B, Kricker J, Magnusson M, Gudjonsson T Curr Mol Biol Rep. 2017; 1(4):168-174.

PMID: 28680803 PMC: 5487766. DOI: 10.1007/s40610-015-0027-x.

LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development.

Acosta D, Bagchi S, Broin P, Hollern D, Racedo S, Morrow B Sci Rep. 2016; 6:35810.

PMID: 27808166 PMC: 5093903. DOI: 10.1038/srep35810.

References

Ingber D . Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol. 1997; 59:575-99. DOI: 10.1146/annurev.physiol.59.1.575. View

BATSAKIS J, El-Naggar A . Myoepithelium in salivary and mammary neoplasms is host-friendly. Adv Anat Pathol. 1999; 6(4):218-26. View

Dawson E . A Histological Study of the Normal Mamma in Relation to Tumour Growth. I.-Early Development to Maturity. Edinb Med J. 2018; 41(12):653-682. PMC: 5329441. View

Cooper D, Schermer A, Sun T . Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab Invest. 1985; 52(3):243-56. View

Signoretti S, Waltregny D, Dilks J, Isaac B, Lin D, Garraway L . p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol. 2000; 157(6):1769-75. PMC: 1885786. DOI: 10.1016/S0002-9440(10)64814-6. View

Gusterson B, Monaghan P, Mahendran R, Ellis J, OHare M . Identification of myoepithelial cells in human and rat breasts by anti-common acute lymphoblastic leukemia antigen antibody A12. J Natl Cancer Inst. 1986; 77(2):343-9. View

Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S . p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A. 2001; 98(6):3156-61. PMC: 30623. DOI: 10.1073/pnas.061032098. View

Gudjonsson T, Ronnov-Jessen L, Villadsen R, Rank F, Bissell M, Petersen O . Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci. 2002; 115(Pt 1):39-50. PMC: 2933194. DOI: 10.1242/jcs.115.1.39. View

Deugnier M, Teuliere J, Faraldo M, Thiery J, Glukhova M . The importance of being a myoepithelial cell. Breast Cancer Res. 2002; 4(6):224-30. PMC: 137933. DOI: 10.1186/bcr459. View

10.

Domagala W, Striker G, Szadowska A, Dukowicz A, Harezga B, Osborn M . p53 protein and vimentin in invasive ductal NOS breast carcinoma--relationship with survival and sites of metastases. Eur J Cancer. 1994; 30A(10):1527-34. DOI: 10.1016/0959-8049(94)00288-g. View

11.

Pechoux C, Clezardin P, Dante R, Serre C, Clerget M, Bertin N . Localization of thrombospondin, CD36 and CD51 during prenatal development of the human mammary gland. Differentiation. 1994; 57(2):133-41. DOI: 10.1046/j.1432-0436.1994.5720133.x. View

12.

Jones C, Nonni A, Fulford L, Merrett S, Chaggar R, Eusebi V . CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. Br J Cancer. 2001; 85(3):422-7. PMC: 2364069. DOI: 10.1054/bjoc.2001.1869. View

13.

Osin P, Anbazhagan R, Bartkova J, Nathan B, Gusterson B . Breast development gives insights into breast disease. Histopathology. 1998; 33(3):275-83. DOI: 10.1046/j.1365-2559.1998.00479.x. View

14.

Santini D, Ceccarelli C, Taffurelli M, Pileri S, Marrano D . Differentiation pathways in primary invasive breast carcinoma as suggested by intermediate filament and biopathological marker expression. J Pathol. 1996; 179(4):386-91. DOI: 10.1002/(SICI)1096-9896(199608)179:4<386::AID-PATH631>3.0.CO;2-V. View

15.

Foschini M, Eusebi V . Carcinomas of the breast showing myoepithelial cell differentiation. A review of the literature. Virchows Arch. 1998; 432(4):303-10. DOI: 10.1007/s004280050170. View

16.

Stingl J, Eaves C, Zandieh I, Emerman J . Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Res Treat. 2001; 67(2):93-109. DOI: 10.1023/a:1010615124301. View

17.

Petersen O, Ronnov-Jessen L, Weaver V, Bissell M . Differentiation and cancer in the mammary gland: shedding light on an old dichotomy. Adv Cancer Res. 1998; 75:135-61. PMC: 3867313. DOI: 10.1016/s0065-230x(08)60741-1. View

18.

Hagios C, Lochter A, Bissell M . Tissue architecture: the ultimate regulator of epithelial function?. Philos Trans R Soc Lond B Biol Sci. 1998; 353(1370):857-70. PMC: 1692274. DOI: 10.1098/rstb.1998.0250. View

19.

Perou C, Sorlie T, Eisen M, van de Rijn M, Jeffrey S, Rees C . Molecular portraits of human breast tumours. Nature. 2000; 406(6797):747-52. DOI: 10.1038/35021093. View

20.

De Potter C, Van Daele S, van de Vijver M, Pauwels C, Maertens G, De Boever J . The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues. Histopathology. 1989; 15(4):351-62. DOI: 10.1111/j.1365-2559.1989.tb01587.x. View