Single Gene Disorders Causing Ischaemic Stroke

Overview

Journal J Neurol

Specialty Neurology

Date 2006 Jun 30

PMID 16807686

Citations 9

Authors

Saif S M Razvi

Ian Bone

Affiliations

Soon will be listed here.

Abstract

Stroke is the third most common cause of death and the leading cause of long-term neurological disability in the world. Conventional vascular risk factors for stroke contribute approximately to only forty to fifty percent of stroke risk. Genetic factors may therefore contribute to a significant proportion of stroke and may be polygenic, monogenic or multi-factorial. Monogenic (single gene) disorders may potentially account for approximately one percent of all ischaemic stroke. Monogenic stroke disorders include conditions such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) and hereditary endotheliopathy, retinopathy, nephropathy and stroke (HERNS). In addition, other monogenic conditions such as sickle cell and Fabry disease also lead to stroke. These monogenic disorders cause either small vessel or large vessel stroke (or a combination of both) and serve as useful models for understanding and studying conventional stroke and cerebrovascular disease and its accompaniments such as vascular dementia.

Citing Articles

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.

Lecordier S, Manrique-Castano D, El Moghrabi Y, ElAli A Front Aging Neurosci. 2021; 13:727590.

PMID: 34566627 PMC: 8461067. DOI: 10.3389/fnagi.2021.727590.

Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach.

Polivka Jr J, Polivka J, Pesta M, Rohan V, Celedova L, Mahajani S EPMA J. 2019; 10(1):81-99.

PMID: 30984317 PMC: 6459458. DOI: 10.1007/s13167-019-00162-5.

Morphogenetic Variability and Hypertension in Ischemic Stroke Patients-Preliminary Study.

Savic M, Cvjeticanin S, Lazovic M, Nikcevic L, Nikolic D J Clin Med. 2018; 7(7).

PMID: 29949901 PMC: 6068471. DOI: 10.3390/jcm7070162.

Vascular dementia: Diagnostic criteria and supplementary exams. Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology. Part I.

Engelhardt E, Tocquer C, Andre C, Moreira D, Okamoto I, Cavalcanti J Dement Neuropsychol. 2017; 5(4):251-263.

PMID: 29213752 PMC: 5619038. DOI: 10.1590/S1980-57642011DN05040003.

Genetics of ischaemic stroke in young adults.

Terni E, Giannini N, Brondi M, Montano V, Bonuccelli U, Mancuso M BBA Clin. 2015; 3:96-106.

PMID: 26672892 PMC: 4661509. DOI: 10.1016/j.bbacli.2014.12.004.

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