Raman Spectroscopy: the Gateway into Tomorrow's Virology

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2006 Jun 30

PMID 16805914

Citations 12

Authors

Phelps J Lambert

Audy G Whitman

Ossie F Dyson

Shaw M Akula

Affiliations

Soon will be listed here.

Abstract

In the molecular world, researchers act as detectives working hard to unravel the mysteries surrounding cells. One of the researchers' greatest tools in this endeavor has been Raman spectroscopy. Raman spectroscopy is a spectroscopic technique that measures the unique Raman spectra for every type of biological molecule. As such, Raman spectroscopy has the potential to provide scientists with a library of spectra that can be used to unravel the makeup of an unknown molecule. However, this technique is limited in that it is not able to manipulate particular structures without disturbing their unique environment. Recently, a novel technology that combines Raman spectroscopy with optical tweezers, termed Raman tweezers, evades this problem due to its ability to manipulate a sample without physical contact. As such, Raman tweezers has the potential to become an incredibly effective diagnostic tool for differentially distinguishing tissue, and therefore holds great promise in the field of virology for distinguishing between various virally infected cells. This review provides an introduction for a virologist into the world of spectroscopy and explores many of the potential applications of Raman tweezers in virology.

Citing Articles

Raman spectroscopy of lymphocytes from patients with the Epstein-Barr virus infection.

Pietruszewska M, Biesiada G, Czepiel J, Birczynska-Zych M, Moskal P, Garlicki A Sci Rep. 2024; 14(1):6417.

PMID: 38494496 PMC: 10944829. DOI: 10.1038/s41598-024-56864-y.

Raman Multi-Omic Snapshot and Statistical Validation of Structural Differences between Herpes Simplex Type I and Epstein-Barr Viruses.

Pezzotti G, Ohgitani E, Imamura H, Ikegami S, Shin-Ya M, Adachi T Int J Mol Sci. 2023; 24(21).

PMID: 37958551 PMC: 10647490. DOI: 10.3390/ijms242115567.

Understanding the role of membrane cholesterol upon Epstein Barr virus infection in astroglial cells.

Rani A, Tanwar M, Verma T, Patra P, Trivedi P, Kumar R Front Immunol. 2023; 14:1192032.

PMID: 37876925 PMC: 10591182. DOI: 10.3389/fimmu.2023.1192032.

Optical Biosensors for the Diagnosis of COVID-19 and Other Viruses-A Review.

John P, Vasa N, Zam A Diagnostics (Basel). 2023; 13(14).

PMID: 37510162 PMC: 10378272. DOI: 10.3390/diagnostics13142418.

Raman Microspectroscopy Goes Viral: Infection Dynamics in the Cosmopolitan Microalga, .

Yakubovskaya E, Zaliznyak T, Martinez Martinez J, Taylor G Front Microbiol. 2021; 12:686287.

PMID: 34795644 PMC: 8593419. DOI: 10.3389/fmicb.2021.686287.

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