Laryngeal Leiomyosarcoma: a Case Report and Review of the Literature

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2006 Jun 29

PMID 16804717

Citations 7

Authors

Charalambos E Skoulakis

Pelagia Stavroulaki

Panagiotis Moschotzopoulos

Mihalis Paxinos

Angela Fericean

Dimitris E Valagiannis

Affiliations

Soon will be listed here.

Abstract

Laryngeal leiomyosarcoma (LLM) is a rare malignancy originating from the smooth muscles of blood vessels or from aberrant undifferentiated mesenchymal tissue. Histological diagnosis may be particularly difficult and correct diagnosis is based on immunohistochemical investigations and electron microscopy. A case report of a LLM in a 74-year-old man is presented. Direct laryngoscopy revealed a large glottic lesion causing airway compromise and an emergency tracheotomy was performed. Subsequent total laryngectomy confirmed the diagnosis of leiomyosarcoma. Lung metastases developed 8 months following treatment, despite the absence of local or regional recurrence, and the patient died 3 months later. A review of the English and French literature revealed 30 previous cases of LLM. Clinical presentation, histological diagnosis, and management of this rare malignancy are analyzed aiming to improve our knowledge regarding the best treatment modality.

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