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Amyloid Load and Cerebral Atrophy in Alzheimer's Disease: an 11C-PIB Positron Emission Tomography Study

Overview
Journal Ann Neurol
Specialty Neurology
Date 2006 Jun 28
PMID 16802294
Citations 76
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Abstract

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

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