Diagnosis of Primary Esophageal Synovial Sarcoma by Demonstration of T(X;18) Translocation: a Case Report

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2006 Jun 22

PMID 16788828

Citations 6

Authors

Catherine Butori

Veronique Hofman

Rita Attias

Jerome Mouroux

Florence Pedeutour

Paul Hofman

Affiliations

Soon will be listed here.

Abstract

Synovial sarcoma (SS) is an uncommon soft tissue tumor occurring mainly in the periarticular region of the extremities of young adults. In this report, we describe a very rare occurrence of primary SS of the esophagus in a 72-year-old woman. Histologically, the tumor demonstrated biphasic morphologic findings associated with poorly differentiated areas. Tumor cells expressed vimentin, epithelial (EMA, CK7, AE1/3), bcl-2 and neuroectodermal (CD56, CD57, CD99) antigens. Differential diagnose included esophageal sarcomatoid carcinoma. Cytogenetic analysis confirmed the diagnosis of SS by identifying t(X;18) translocation. The literature of this very uncommon entity of the esophagus is reviewed.

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References

Ohtaka M, Kumasaka T, Nobukawa B, Hirai S, Suda K, Ohno Y . Carcinosarcoma of the esophagus characterized by myoepithelial and ductal differentiations. Pathol Int. 2002; 52(10):657-63. DOI: 10.1046/j.1440-1827.2002.01407.x. View

Limon J, Dal Cin P, Sandberg A . Application of long-term collagenase disaggregation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet. 1986; 23(4):305-13. DOI: 10.1016/0165-4608(86)90013-0. View

Amr S, Shihabi N, Al Hajj H . Synovial sarcoma of the esophagus. Am J Otolaryngol. 1984; 5(4):266-9. DOI: 10.1016/s0196-0709(84)80037-x. View

Palmer B, Levene A, Shaw H . Synovial sarcoma of the pharynx and oesophagus. J Laryngol Otol. 1983; 97(12):1173-6. DOI: 10.1017/s0022215100096171. View

Perch S, Soffen E, Whittington R, Brooks J . Esophageal sarcomas. J Surg Oncol. 1991; 48(3):194-8. DOI: 10.1002/jso.2930480311. View

Kwon M, Hong S, Cho H, Ahn G, Lee S, Lee K . Extensive and divergent chromosomal losses in squamous and spindle-cell components of esophageal sarcomatoid carcinoma. Virchows Arch. 2003; 443(5):635-42. DOI: 10.1007/s00428-003-0873-4. View

Matsumoto T, Fujii H, Arakawa A, Yamasaki S, Sonoue H, Hattori K . Loss of heterozygosity analysis shows monoclonal evolution with frequent genetic progression and divergence in esophageal carcinosarcoma. Hum Pathol. 2004; 35(3):322-7. DOI: 10.1016/j.humpath.2003.02.001. View

Nilsson G, Skytting B, Xie Y, Brodin B, Perfekt R, Mandahl N . The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Cancer Res. 1999; 59(13):3180-4. View

Habu S, Okamoto E, Toyosaka A, Nakai Y, Takeuchi M . Synovial sarcoma of the esophagus: report of a case. Surg Today. 1998; 28(4):401-4. DOI: 10.1007/s005950050149. View

10.

Fisher C . Synovial sarcoma. Ann Diagn Pathol. 1999; 2(6):401-21. DOI: 10.1016/s1092-9134(98)80042-7. View

11.

Billings S, Meisner L, Cummings O, Tejada E . Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization. Mod Pathol. 2000; 13(1):68-76. DOI: 10.1038/modpathol.3880011. View

12.

Kawauchi S, Fukuda T, Oda Y, Saito T, Oga A, Takeshita M . Prognostic significance of apoptosis in synovial sarcoma: correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins. Mod Pathol. 2000; 13(7):755-65. DOI: 10.1038/modpathol.3880131. View

13.

Hasegawa T, Yamamoto S, Nojima T, Hirose T, Nikaido T, Yamashiro K . Validity and reproducibility of histologic diagnosis and grading for adult soft-tissue sarcomas. Hum Pathol. 2002; 33(1):111-5. DOI: 10.1053/hupa.2002.30184. View

14.

Bonavina L, Fociani P, Asnaghi D, Ferrero S . Synovial sarcoma of the esophagus simulating achalasia. Dis Esophagus. 1999; 11(4):268-71. DOI: 10.1093/dote/11.4.268. View

15.

Bloch M, Iozzo R, EDMUNDS Jr L, Brooks J . Polypoid synovial sarcoma of the esophagus. Gastroenterology. 1987; 92(1):229-33. DOI: 10.1016/0016-5085(87)90865-1. View

16.

Trassard M, Le Doussal V, Hacene K, Terrier P, Ranchere D, Guillou L . Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients. J Clin Oncol. 2001; 19(2):525-34. DOI: 10.1200/JCO.2001.19.2.525. View

17.

Rosen G, Forscher C, Lowenbraun S, Eilber F, Eckardt J, Holmes C . Synovial sarcoma. Uniform response of metastases to high dose ifosfamide. Cancer. 1994; 73(10):2506-11. DOI: 10.1002/1097-0142(19940515)73:10<2506::aid-cncr2820731009>3.0.co;2-s. View

18.

Anton-Pacheco J, Cano I, Cuadros J, Vilarino A, Berchi F . Synovial sarcoma of the esophagus. J Pediatr Surg. 1996; 31(12):1703-5. DOI: 10.1016/s0022-3468(96)90057-3. View