Multiple Pathways Transmit Neuroprotective Effects of Gonadal Steroids

Overview

Journal Endocrine

Specialty Endocrinology

Date 2006 Jun 21

PMID 16785596

Citations 45

Authors

Damani N Bryant

Laird C Sheldahl

Lisa K Marriott

Robert A Shapiro

Daniel M Dorsa

Affiliations

Soon will be listed here.

Abstract

Numerous preclinical studies suggest that gonadal steroids, particularly estrogen, may be neuroprotective against insult or disease progression. This paper reviews the mechanisms contributing to estrogen-mediated neuroprotection. Rapid signaling pathways, such as MAPK, PI3K, Akt, and PKC, are required for estrogen's ability to provide neuroprotection. These rapid signaling pathways converge on genomic pathways to modulate transcription of E2-responsive genes via ERE-dependent and ERE-independent mechanisms. It is clear that both rapid signaling and transcription are important for estrogen's neuroprotective effects. A mechanistic understanding of estrogen-mediated neuroprotection is crucial for the development of therapeutic interventions that enhance quality of life without deleterious side effects.

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