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1,3-diketones from Acid Chlorides and Ketones: a Rapid and General One-pot Synthesis of Pyrazoles

Overview
Journal Org Lett
Specialties Biochemistry
Chemistry
Date 2006 Jun 16
PMID 16774229
Citations 24
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Abstract

[reaction: see text] 1,3-Diketones were synthesized directly from ketones and acid chlorides and were then converted in situ into pyrazoles by the addition of hydrazine. This method is extremely fast, general, and chemoselective, allowing for the synthesis of previously inaccessible pyrazoles and synthetically demanding pyrazole-containing fused rings.

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