Association Between Plasma Homocysteine Concentrations and Extracranial Carotid Stenosis

Overview

Journal Ann Saudi Med

Specialty General Medicine

Date 2006 Jun 10

PMID 16761449

Citations 2

Authors

Seyed Ali Mousavi

Majid Ghasemi

Tahereh Hoseini

Affiliations

Soon will be listed here.

Abstract

Background: Increasing epidemiologic data support a relationship between elevated plasma total homocysteine levels and an increased risk for vascular disease. Higher plasma total homocysteine (tHcy) levels have been associated with extracranial carotid atherosclerosis and cerebral infarction in whites. However, data regarding such associations are limited for Asians. This study examined the association between tHcy level and carotid stenosis in Iranian subjects.

Patients And Methods: In this retrospective study, the subjects were 158 patients with ischemic stroke, including 105 with a normal tHcy level and 53 with a high tHcy level. We investigated the extracranial carotid arteries by ultrasonography and measured serum tHcy by the ELISA method in these two groups.

Results: We found no meaningful association between a high tHcy level and carotid stenosis.

Discussion: The lack of any meaningful difference in carotid stenosis between patients with normal and elevated tHcy levels is probably due to the low frequency of extracranial disease in the Asian population and to the nature of homocysteine atherosclerosis.

Citing Articles

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Hyperhomocysteinemia Induced by Methionine Excess Is Effectively Suppressed by Betaine in Geese.

Yang Z, Yang Y, Yang J, Wan X, Yang H, Wang Z Animals (Basel). 2020; 10(9).

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